Development of comprehensive immunotherapy by defuccosylated antibody

利用人肿瘤接种NOG小鼠，模拟人肿瘤的病理特征，包括肿瘤内的微环境，建立了抗原特异性细胞毒性T淋巴细胞（CTL）自体治疗实验模型。在用HTLV-1 Tax特异性CTL输注处理的接种成人T细胞白血病（ATL）细胞的NOG小鼠中证明了显著的治疗效果。由于肿瘤局部免疫动力学的分析对于免疫治疗的发展至关重要，因此本研究中的治疗性小鼠模型将更加重要。

Therapeutic experimental model in autologous system by antigen specific cytotoxic T lymphocyte (CTL) using human tumor inoculated NOG mice which mimic pathological features of human tumor including micro environment in the tumor. Significant therapeutic effect was demonstrated in Adult T-cell leukemia (ATL) cells inoculated NOG mice treated with infusion of HTLV-1 Tax specific CTL. The therapeutic mouse model in our study will be more important because the analysis of immune dynamism in tumor site is essential for the immunotherapy development.