Systems genomics towards system-level understanding of life

系统基因组学对生命的系统级理解

• 批准号: 16063101
• 负责人: TAKAGI Toshihisa
• 金额: $ 309.5万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16063101/
• 关键词: 生命システム; ゲノム機能解析; 生命シミュレーション; バイオインフォマティクス; 遺伝子ネットワーク; 表現型解析; ゲノムオントロジー; システム生物学

The steering group promoted the cooperation among four different research groups in Systems Genomics, one of the four research areas of the new genome reseach project. We also performed a variety of activities to manage the whole research area(that is, not only Systems Genomics but other three areas; Comparative Genomics, Applied Genomics, and Comprehensive Genomics) organically and smoothly, so that they can promote their research effectively as an entire research area.

指导小组促进了四个不同研究小组在系统基因组学方面的合作，系统基因组学是新基因组研究项目的四个研究领域之一。我们还开展了多种活动，将整个研究领域(不仅是系统基因组学，还有其他三个领域，即比较基因组学、应用基因组学和综合基因组学)有机地、顺畅地进行管理，使它们作为一个整体有效地推进研究。

项目成果

Functional dissection of YabA, a negative regulator of DNA replication initiation in Bacillus subtilis

• DOI: 10.1073/pnas.0506914103
• 发表时间: 2006-02-14
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Noirot-Gros, MF;Velten, M;Noirot, P
• 通讯作者: Noirot, P

Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation

• DOI: 10.1074/jbc.m706158200
• 发表时间: 2007-11-02
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Muramatsu, Shuji;Wakabayashi, Makoto;Matsuda, Akio
• 通讯作者: Matsuda, Akio

Metabolomics approach for determining growth-specific metabolites based on Fourier transform ion cyclotron resonance mass spectrometry.

• DOI: 10.1007/s00216-008-2195-5
• 发表时间: 2008-08
• 期刊: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
• 影响因子: 4.3
• 作者: Takahashi, Hiroki;Kai, Kosuke;Shinbo, Yoko;Tanaka, Kenichi;Ohta, Daisaku;Oshima, Taku;Altaf-Ul-Amin, Md.;Kurokawa, Ken;Ogasawara, Naotake;Kanaya, Shigehiko
• 通讯作者: Kanaya, Shigehiko

A large-scale full-length cDNA analysis to explore the budding yeast transcriptome

• DOI: 10.1073/pnas.0605645103
• 发表时间: 2006-11-21
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Miura, Fumihito;Kawaguchi, Noriko;Ito, Takashi
• 通讯作者: Ito, Takashi

Centaurin-alpha 1 is a PI3K dependent activator of ERK1/2 map kinases.

Centaurin-alpha 1 是 ERK1/2 图激酶的 PI3K 依赖性激活剂。

• 发表时间: 2005
• 期刊: J Biol Chem 281
• 作者: Otsuki;T.;Hayashi H
• 通讯作者: Hayashi H