Functions of RecQ family helicases in DNA replication, repair, and damage avoidance
Functions of RecQ family helicases in DNA replication, repair, and damage avoidance
批准号:
17013005
负责人:
ENOMOTO Takemi
金额:
$45.76万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Human cells possess five RecQ family helicases, RECQL1, BLM, WRN, RTS, and RECQL5, whose defects cause a predisposition to cancer. In this study, functions of these RecQ family helicases were investigated and following results were obtained. BLM functions at the last stage of DNA replication, segregation of replicated DNA and sister chromatid cohesion. RTS is involved in DNA replication and repair of DNA double strand breaks. Finally, RECQL1 and RECQL5 are involved in early stages of recombination.
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RecQL4 functions in Ku and DNA-dependent protein kinase-mediated double-strand break repair in Xenopus egg extracts.
RecQL4 在爪蟾卵提取物中的 Ku 和 DNA 依赖性蛋白激酶介导的双链断裂修复中发挥作用。
DOI:
--
发表时间:
2007
期刊:
Biochim. Biophys. Acta 1773・4
影响因子:
--
作者:
[Sumimoto, H., Kamakura, S., Ito, T, Kiyama S. et. al., Yuji Kumata]
通讯作者:
Yuji Kumata
ブルーム症候群原因遺伝子産物の機能の解析
导致布卢姆综合征的基因产物的功能分析
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[関政幸, 多田周右, 榎本武美]
通讯作者:
榎本武美
蛋白質核酸酵素別冊;染色体サイクル
蛋白质核酸酶分离体积;
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M, 関政幸・Mong Sing Lai・榎本武美]
通讯作者:
関政幸・Mong Sing Lai・榎本武美
Activation of a novel pathway involving Mms1 and Rad59 in sgs1 cells
sgs1 细胞中涉及 Mms1 和 Rad59 的新途径的激活
DOI:
--
发表时间:
2007
期刊:
Biochem. Biophys. Res. Commun 356
影响因子:
--
作者:
[Ui, A., Seki, M., Ogiwara, H., Lai, M.S., Yamamoto, K., Tada, S., Enomoto, T]
通讯作者:
T
INO80 chromatin remodeling complex functions in sister chromatid cohesion
INO80染色质重塑复合体在姐妹染色单体凝聚力中的功能
DOI:
--
发表时间:
2007
期刊:
Cell Cycle 6
影响因子:
--
作者:
[Ogiwara, H., Enomoto, T., Seki, M]
通讯作者:
M
共 90 条
Analyses of function of RecQ helicase and its related proteins and detection of endogenous DNA damaging agents
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批准号:26440065
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2014
-
负责人:ENOMOTO Takemi
-
依托单位:
Functions of RECQL1 and RECQL5 in the maintenance of genome stability
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批准号:23370065
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.73万
-
财政年份:2011
-
负责人:ENOMOTO Takemi
-
依托单位:
Study on the functions of WRN and WRNIP1 that interacts with WRN
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批准号:20390020
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.48万
-
财政年份:2008
-
负责人:ENOMOTO Takemi
-
依托单位:
Studies on the function of Werner syndrome gene product and analyses of the mechanism to induce aging related symptoms
-
批准号:18390019
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.7万
-
财政年份:2006
-
负责人:ENOMOTO Takemi
-
依托单位:
Molecular mechanism to couple DNA replication with avoidance of DNA lesions, the defect in which induces cancer and aging
-
批准号:15390021
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.73万
-
财政年份:2003
-
负责人:ENOMOTO Takemi
-
依托单位:
Molecular mechanism to cause high incidence of cancer in Bloom syndrcme
-
批准号:13214007
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$37.12万
-
财政年份:2001
-
负责人:ENOMOTO Takemi
-
依托单位:
Development of a highly efficient method to integrate genes into genome of higher eukaryotic cells by homologous recombination
-
批准号:12557208
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.62万
-
财政年份:2000
-
负责人:ENOMOTO Takemi
-
依托单位:
Basic study on the mechanisms of carcinogenesis and aging with special reference to the function of RecQ family helicases
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批准号:11307055
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$24.75万
-
财政年份:1999
-
负责人:ENOMOTO Takemi
-
依托单位:
Molecular mechanism of the high incidence of cancer of Bloom's syndrome
-
批准号:11138207
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
-
资助金额:$4.8万
-
财政年份:1999
-
负责人:ENOMOTO Takemi
-
依托单位:
Studies on the roles of RecQ family proteins in DNA repair and recombination in relation to carcinogenesis and aging
-
批准号:09470498
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.27万
-
财政年份:1997
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负责人:ENOMOTO Takemi
-
依托单位:
Novel Mechanism & Developmental Roles of Repair・Recombination
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批准号:07044227
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$4.54万
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财政年份:1995
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负责人:ENOMOTO Takemi
-
依托单位:
Establishment of the basis for developing inhibitors that target the DNA helicase involved in DNA replication
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批准号:07557153
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$8.7万
-
财政年份:1995
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负责人:ENOMOTO Takemi
-
依托单位:
Analysis of signal transduction of insulin with special reference to protein kinase FA
-
批准号:04454599
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$3.71万
-
财政年份:1992
-
负责人:ENOMOTO Takemi
-
依托单位:
Peconstitution and analysis of mammalian DNA replication system in vitro.
-
批准号:60571034
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.09万
-
财政年份:1985
-
负责人:ENOMOTO Takemi
-
依托单位:
海外基金