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Study on the functions of WRN and WRNIP1 that interacts with WRN

Study on the functions of WRN and WRNIP1 that interacts with WRN
WRN及与WRN相互作用的WRNIP1的功能研究
批准号:
20390020
负责人:
ENOMOTO Takemi
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In this project, we tried to identify the DNA damage avoidance pathway in which WRNIP1 is involved and to clarify how to affect RAD18 and WRN this pathway, and obtained the following results.(1) WRNIP1 localized to the region containing DNA single-strand breaks via its N-terminal UBZ domain.(2) RAD18-RAD6 complex bound to replication fork like DNA recruited WRNIP1 to the DNA, and recruited WRNIP1 replaced RAD18-RAD6 complex.(3) WRNIP1 bound to template-primer DNA recruited WRN to the DNA, and recruited WRN replaced WRNIP1.
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会议论文
DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation
DNA-PKcs 和 Artemis 对于大量 DSB 形成后快速诱导细胞凋亡至关重要
DOI: --
发表时间: 2008
期刊: Cell Signal. 20
影响因子: --
作者: [Abe, T.]
通讯作者: T.
The N-terminal region of RECQL4 Lacking the helicase domain is both essential and sufficient for the viavility of vertebrate.
RECQL4 的 N 末端区域缺少解旋酶结构域,这对于脊椎动物的生存能力来说既是必需的,也是足够的。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [大前英司, 村上千穂, 楯真一, 月向邦彦, 加藤千明, 橋口太志, 吉村明]
通讯作者: 吉村明
Analysis of DNA replication repression by excess Cdt1
过量 Cdt1 对 DNA 复制抑制的分析
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Sasaki M, Hamada K, Kawahara K, Sasaki T, Maehama T, Suzuki A, 大隅達也, 牛田磨理]
通讯作者: 牛田磨理
Phenyl hydroquinone, an Ames test-negative carcinogen, induces Hogl-dependent stress response signaling : Implication for aneuploidy development in Saccharomyces cerevisiae
苯基对苯二酚是一种艾姆斯试验阴性致癌物,可诱导 Hogl 依赖性应激反应信号传导:对酿酒酵母非整倍体发育的影响
DOI: --
发表时间: 2008
期刊: FEBS J. 275
影响因子: --
作者: [Yamamoto, A.]
通讯作者: A.
41
    Analyses of function of RecQ helicase and its related proteins and detection of endogenous DNA damaging agents
    • 批准号:
      26440065
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2014
    • 负责人:
      ENOMOTO Takemi
    • 依托单位:
    Functions of RECQL1 and RECQL5 in the maintenance of genome stability
    • 批准号:
      23370065
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.73万
    • 财政年份:
      2011
    • 负责人:
      ENOMOTO Takemi
    • 依托单位:
    Studies on the function of Werner syndrome gene product and analyses of the mechanism to induce aging related symptoms
    • 批准号:
      18390019
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.7万
    • 财政年份:
      2006
    • 负责人:
      ENOMOTO Takemi
    • 依托单位:
    Functions of RecQ family helicases in DNA replication, repair, and damage avoidance
    • 批准号:
      17013005
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $45.76万
    • 财政年份:
      2005
    • 负责人:
      ENOMOTO Takemi
    • 依托单位:
    国内基金
    海外基金
    基于氮氧自由基荧光前体的耐辐射硅橡胶及其早期老化监测研究