Regulation of cell attachment and motility by Src-mediated signal pathways.

Src 介导的信号通路对细胞附着和运动的调节。

• 批准号: 17014040
• 负责人: HAMAGUCHI Michinari
• 金额: $ 29.06万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17014040/
• 关键词: Src; FAK; MMP; invasion; cytokine; nitric oxide; 一酸化窒素; システイン; ニトロソ化; チロシンキナーゼ; Gap Junction; Focal Contact; Adherence Junction; Srcキナーゼ; シグナル伝達系; β-catenin; SHPS-1; 足場非依存細胞増殖; 細胞間接着; 微小管; 細胞癌化; コネキシン; ギャップ結合; Ras

The Src kinase is often activated in breast cancer and colon cancer. We have been investigating the mechanisms of how Src kinase activates MMP secretion and enhances cell invasion. We have found cytokines such as TNFalpha and IL-1beta activated Src and FAK, which was required for the stimulation of MMP-9 secretion and cell invasion. We also found that nitric oxide induced cell invasion, which was dependent on the activation of FAK and Src by S-nitrosylation.

Src激酶通常在乳腺癌和结肠癌中被激活。我们一直在研究Src激酶如何激活MMP分泌和增强细胞侵袭的机制。我们已经发现细胞因子如TNF α和IL-1 β激活Src和FAK，这是刺激MMP-9分泌和细胞侵袭所必需的。我们还发现，一氧化氮诱导的细胞侵袭，这是依赖于激活FAK和Src的S-亚硝基化。

项目成果

Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling.

• DOI: 10.3892/ijo_00000341
• 发表时间: 2009-08
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Hong Yuan;S. Ito;T. Senga;T. Hyodo;T. Kiyono;F. Kikkawa;M. Hamaguchi

MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth

MEK抑制剂增强伊马替尼对胰腺癌细胞生长的抑制作用

• 发表时间: 2008
• 期刊: Cancer Lett. 264(2)
• 作者: Takayama Y;Kokuryo T;Yokoyama Y;Nagino M;Nimura Y;Senga T;Hamaguchi M.
• 通讯作者: Hamaguchi M.

FAK Signaling in Neoplastic Disorder: A Linkage between Inflammation and Cancer

肿瘤疾病中的 FAK 信号传导：炎症与癌症之间的联系

• 发表时间: 2007
• 作者: 兵頭寿典;伊藤聡子;千賀威;浜口道成;M. Hamaguchi
• 通讯作者: M. Hamaguchi

POLIM1 is involved in cell spreading and interact with palladin

POLIM1 参与细胞扩散并与 Palladin 相互作用

• 发表时间: 2007
• 作者: M. Maeda;M. Hamaguchi;et. al.
• 通讯作者: et. al.

Nek2 as a novel molecular target for the treatment of breast carcinoma

• DOI: 10.1111/j.1349-7006.2008.01007.x
• 发表时间: 2009-01-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Tsunoda, Nobuyuki;Kokuryo, Toshio;Hamaguchi, Michinari
• 通讯作者: Hamaguchi, Michinari