Regulation of cell attachment and motility by Src-mediated signal pathways.

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The Src kinase is often activated in breast cancer and colon cancer. We have been investigating the mechanisms of how Src kinase activates MMP secretion and enhances cell invasion. We have found cytokines such as TNFalpha and IL-1beta activated Src and FAK, which was required for the stimulation of MMP-9 secretion and cell invasion. We also found that nitric oxide induced cell invasion, which was dependent on the activation of FAK and Src by S-nitrosylation.