Regulation of cell attachment and motility by Src-mediated signal pathways.

Src激酶在乳腺癌和结肠癌中经常被激活。我们一直在研究Src激酶如何激活MMP分泌并增强细胞侵袭的机制。我们发现细胞因子如TNFalpha和il -1 β激活Src和FAK，这是刺激MMP-9分泌和细胞侵袭所必需的。我们还发现一氧化氮诱导细胞侵袭，这依赖于s -亚硝基化对FAK和Src的激活。

The Src kinase is often activated in breast cancer and colon cancer. We have been investigating the mechanisms of how Src kinase activates MMP secretion and enhances cell invasion. We have found cytokines such as TNFalpha and IL-1beta activated Src and FAK, which was required for the stimulation of MMP-9 secretion and cell invasion. We also found that nitric oxide induced cell invasion, which was dependent on the activation of FAK and Src by S-nitrosylation.