Cancer epidemiological studies for Japanese immigrants and development of preventive strategy for cancer based on the evidence from the studies

日本移民的癌症流行病学研究以及基于研究证据的癌症预防策略的制定

• 批准号: 17015049
• 负责人: TSUGANE Shoichiro
• 金额: $ 30.85万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015049/
• 关键词: ブラジル日系移民; がん; 乳がん; 大腸腺腫; 症例対照研究; 断面研究; 環境要因; 遺伝的素因

We have conducted epidemiological studies such as cross-sectional and case-control study among Japanese Brazilians living in Sao Paulo. In case-control studies for breast cancer, we analyzed data from in three populations : Japanese living in Japan, Japanese Brazilians living in Sao Paulo, and non-Japanese Brazilians living in Sao Paulo. We found an inverse association between isoflavone intake and breast cancer risk, and stratified analysis suggested that polymorphisms in the estrogen receptor beta, 17β-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. We found no overall association between folate, vitamin B6, and vitamin B12 intake and the risk of breast cancer. In a cross-sectional study of colorectal adenoma among Japanese Brazilians living in Sao Paulo, Brazil, participants have been recruited in two hospitals and we completed a survey from 719 participates at the end of March, 2010.

我们在生活在圣保罗的日裔巴西人中进行了流行病学研究，如横断面研究和病例对照研究。在乳腺癌的病例对照研究中，我们分析了三个人群的数据：居住在日本的日本人，居住在圣保罗的日裔巴西人和居住在圣保罗的非日裔巴西人。我们发现维生素B1摄入量与乳腺癌风险呈负相关，分层分析表明雌激素受体β、17β-HSD 1和SHBG基因多态性可能改变维生素B1摄入量与乳腺癌风险之间的关联。我们发现叶酸、维生素B6和维生素B12摄入量与乳腺癌风险之间没有总体关联。在一项生活在巴西圣保罗的巴西日裔结直肠腺瘤的横断面研究中，在两家医院招募了参与者，我们在2010年3月底完成了对719名参与者的调查。

项目成果

Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.

• DOI: 10.1186/1471-2407-9-122
• 发表时间: 2009-04-24
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Ma E;Iwasaki M;Junko I;Hamada GS;Nishimoto IN;Carvalho SM;Motola J Jr;Laginha FM;Tsugane S
• 通讯作者: Tsugane S

Dietary isoflavone intake, polymorphisms in CYP17, CYP19, 17 β-HSD1 and SHBG genes, and the risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.

在日本人、日本巴西人和非日本巴西人的病例对照研究中，膳食异黄酮摄入量、CYP17、CYP19、17 β-HSD1 和 SHBG 基因的多态性以及乳腺癌风险。

• 发表时间: 2008
• 作者: Tsugane S;Iwasaki M;Hamada GS;Nishimoto IN;Netto MM;Motola J Jr;Laginha FM;Kasuga Y;Yokoyama S;Onuma H;Nishimura H;Kusama R;Kobayashi M;Ishihara J;Yamamoto S;Hanaoka T.
• 通讯作者: Hanaoka T.

Heterocyclic amines content of meat and fish cooked by Brazilian methods.

• DOI: 10.1016/j.jfca.2009.07.004
• 发表时间: 2010-02-01
• 期刊: Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems
• 作者: Iwasaki M;Kataoka H;Ishihara J;Takachi R;Hamada GS;Sharma S;Le Marchand L;Tsugane S
• 通讯作者: Tsugane S

Dietary Intake of Folate, Vitamin B2, Vitamin B6, and Vitamin B12, Genetic Polymorphism of Related Enzymes, and Risk of Breast Cancer: a Case-control Study in Japan.

叶酸、维生素 B2、维生素 B6 和维生素 B12 的膳食摄入量、相关酶的遗传多态性和乳腺癌风险：日本的一项病例对照研究。

• 发表时间: 2009
• 期刊: Nutr Cancer (In press)
• 作者: Ma E;et al.
• 通讯作者: et al.

Nutritional Composition of Dishes Commonly Consumed by Japanese Brazilians in Sao Paulo, Brazil.

巴西圣保罗的日本巴西人常吃的菜肴的营养成分。

• 发表时间: 2010
• 期刊: Int J Food Sci Nutr (In press)
• 作者: Sharma S;et al.
• 通讯作者: et al.