Epidemiological Study on Diet and Cancer among Japanese Brazilian

在巴西进行了关于饮食与癌症的流行病学研究，巴西是一个多民族的国家，有120万日裔居民。在圣保罗随机选择了191名日裔巴西人进行了一项饮食记录调查，并对这些数据进行了营养计算。对111名在利马随机选择的秘鲁日裔人的饮食习惯进行了横断面研究，并从他们那里获得了食物频率数据和血液样本。在巴西的肺癌对照研究表明，吸烟的风险与CYP 1A 1的外显子7多态性相互作用。在巴西也进行了胃癌的对照研究，从101名日本人收集了问卷数据血液成分（63名男性和38名女性）和248名非日本人（179名男性和69名女性）胃癌病例和他们在圣保罗地区的对照。血液样品用于实验室测定如胃蛋白酶原测量，幽门螺杆菌抗体分析和DNA提取用于基因分型：非日裔巴西人一生吸烟量超过50包-年与胃癌风险增加显著相关（与从不吸烟者相比，OR=1.8），但对日裔巴西人来说并非如此。在两组中，经常食用油炸食品都与风险增加有关，而每天食用牛肉只会增加日裔巴西人的风险（与月消费量相比OR=3.7）。经常摄入水果和蔬菜与降低胃癌风险有关，这种联系在非胃癌患者中非常显著。日本巴西人谁消耗较少的水果和蔬菜比日本巴西人。这些研究结果表明，风险因素各不相同的种族群体，可能与遗传背景和/或暴露水平的环境因素。

Epidemiological studies on diet and cancer have been conducted in Brazil, a multi-ethnic nation with 1.2 million residents of Japanese ancestry.A dietary record survey was applied to randomly selected Japanese Brazilians in Sao Paulo and a 3 day dietary record obtained from 191 subjects.Nutritional caluculation is on-going for these data.A cross-sectional study of dietary habits was conducted in 111 randomly selected Japanese Peruvians in Lima and food frequency data and blood samples obtained from them.A case-control study of lung cancer in Brazil suggested that the risk of cigarette smoking interacted with the exon 7 polymorphism of CYP1A1.A case-control study of stomach cancer has also been done in Brazil.Questionnaire data blood components were collected from 101 Japanese (63 males and 38 females) and 248 non-Japanese (179 males and 69 females) cases of gastric cancer and their controls in the Sao Paulo area.The blood samples were used for laboratory assays such as pepsinogen measurement, Helicobactor pylori antibody analysis and DNA extraction for genotyping.Life-time cigarette consumption over 50 pack-years was significantly associated with increased risk of stomach cancer for non-Japanese Brazilians (OR=1.8 compared with never smoking), but not for Japanese Brazilians.Frequent consumption of fried food was associated with increased risk in both groups, while daily beef consumption increased the risk only in Japanese Brazilians (OR=3.7 compared with monthly consumption).In adittion, frequent fruit and vegetable intake was associated with reduced risk of stomach cancer and this association was remarkable in non-Japanese Brazilians who consumed less fruit and vegetables than Japanese Brazilians.These findings suggest that the risk factors vary among ethnic groups and may be related to genetic background and/or exposure levels of environmental factors.