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Diet, genetic factor and cancer in Japanese Brazilian

日本巴西人的饮食、遗传因素和癌症

基本信息

批准号：
08042014
负责人：
TSUGANE Shoichiro
金额：
$ 2.94万
依托单位：
National Cancer Center
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1996
资助国家：
日本
起止时间：
1996 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08042014/
关键词：
Japanese immigrants Brazil Carcinogenic factor Dietary habit Genetic factor Cross-sectional study Case-control study Stomach cancer

项目摘要

(1)Cross-sectional studyWe obtained a 3 day dietary record form 166 randomly sampled Japanese Brazilians aged 47 to 75 years in Sao Paulo and compared these data with five Japanese populations in Japan. Japanese Brazilians consumed more sugar and sweats, beans, fruits, chickes and red meats, while less soybean products, vegetables and pickled vegetables. We tried to detect heterocyclic amine-DNA adducts such as dG-C8-MeIQx and dG-C8-PhIP in liver, kidney and colon tissues from autopsy cases and in colon tissues from colon cancer patients, however all samples were less than our detection limit of measurement method.(2)Case-control study of stomach cancerCases were 101 Japanese Brazilians and 245 non-Japanese Brazilian with stomach cancer and controls were 202 and 245 patients without cancer, respectively. Beef consumption was associated with increased risk of stomach cancer in Japanese, while this association was not found in non-Japanese. Vegetable intake was associated with reduced risk in non-Japanese, while not in Japanese. These discordance of dietary risk factors may be cause by different intake level of these foods between two groups. The distributions of RsaI polymorphism of CYPIIE1 were similar between cases and controls in both groups, however these were significantly different between Japanese and non-Japanese.

(1)横断面研究我们从圣保罗随机抽取了166名年龄在47岁至75岁之间的日裔巴西人的3天饮食记录，并将这些数据与日本的5名日本人进行了比较。日裔巴西人摄入的糖、汗、豆类、水果、鸡肉和红肉更多，而豆制品、蔬菜和腌制蔬菜则较少。我们尝试在尸检病例的肝脏、肾脏和结肠组织以及结肠癌患者的结肠组织中检测到dG-C8-MeIQx和dG-C8-PhIP等杂环胺- dna加合物，但所有样本均低于我们测量方法的检出限。(2)胃癌病例-对照研究日本巴西人和非日本巴西人胃癌病例分别为101例和245例，对照组为202例和245例无癌患者。日本人食用牛肉与胃癌风险增加有关，而非日本人没有发现这种联系。非日本人的蔬菜摄入量与风险降低有关，而日本人则不然。这些饮食危险因素的不一致可能是由于两组之间这些食物的摄入水平不同造成的。CYPIIE1 RsaI多态性在两组病例和对照组之间分布相似，但在日本人和非日本人之间存在显著差异。