Functional Genomics based upon mouse inter-subspecific consomic strain

基于两个小鼠亚种之间的大基因组和表型差异，我们开发了一个小鼠功能基因组学分析平台。通过将标准近交系C57BL/6J的每条染色体替换为日本野生小鼠衍生的MSM/Ms，对一组小鼠亚特异性间经济系进行了系统表型分析，成功检测到200多个影响生长、代谢和行为复杂性状的qtl。此外，我们还构建了基因组和表型数据库，整合了经济菌株检测到的snp和qtl。这些数据库现在对公众开放。

Based upon large genomic and phenotypic differences between two mouse subspecies, we have developed an analytic platform for mouse functional genomics. Systematic phenotyping of a full set of mouse inter-subspecific consomic strains, in which each chromosome of a standard inbred strain C57BL/6J is replaced by its counter part of Japanese wild mice-derived MSM/Ms, successfully detected more than 200 QTLs that affect growth, metabolism, and behavioral complex traits. Beside, we have constructed genome and phenotype databases, integrating SNPs and the QTLs detected by the consomic strains. These databases are now open to public.