Functional Genomics based upon mouse inter-subspecific consomic strain
Functional Genomics based upon mouse inter-subspecific consomic strain
批准号:
17018033
负责人:
SHIROISHI Toshihiko
金额:
$114.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Based upon large genomic and phenotypic differences between two mouse subspecies, we have developed an analytic platform for mouse functional genomics. Systematic phenotyping of a full set of mouse inter-subspecific consomic strains, in which each chromosome of a standard inbred strain C57BL/6J is replaced by its counter part of Japanese wild mice-derived MSM/Ms, successfully detected more than 200 QTLs that affect growth, metabolism, and behavioral complex traits. Beside, we have constructed genome and phenotype databases, integrating SNPs and the QTLs detected by the consomic strains. These databases are now open to public.
期刊论文(102)
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糖尿病研究におけるforward geneticsアプローチ
糖尿病研究中的正向遗传学方法
DOI:
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发表时间:
2008
期刊:
影响因子:
--
作者:
[Takeo Suzuki, Tomoyuki Numata, Takuo Osawa, Tsutomu Suzuki, 城石俊彦]
通讯作者:
城石俊彦
Complex genetic architecture of social interaction and aggressive behavior clarified using consomic strains derived from MSM and C57BL/6.
使用源自 MSM 和 C57BL/6 的染色体菌株阐明了社会互动和攻击行为的复杂遗传结构。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Takahashi, A., Sugimoto, H., Kimura, S., Tomihara, K., Tsuchiya, T., Kakihara, S., Tanemura, M., Shiroishi, T., Koide, T.]
通讯作者:
T.
Genetic analysis of inter-male aggression using consomic mouse strains established from C57BL/6J and MSM
使用 C57BL/6J 和 MSM 建立的体体小鼠品系进行雄性间攻击行为的遗传分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Takahashi, A., Tomihara, K., Shiroishi, T., Koide, T.]
通讯作者:
T.
Aberrant neurological development caused by genetic incompatibility between two wild-derived mouse strains.
两种野生小鼠品系之间的遗传不相容性导致神经发育异常。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Umemori, J., Kondou, R., Uno, T., Yuasa, S., Koide, T.:]
通讯作者:
T.:
Molecular evolution of cadherin-related neuronal receptor/protocadherin a (CNR/Pcdha) gene cluster in Mus musculus subspecies.
小家鼠亚种钙粘蛋白相关神经元受体/原钙粘蛋白 a (CNR/Pcdha) 基因簇的分子进化。
DOI:
--
发表时间:
2005
期刊:
Mol.Biol.Evol. 22
影响因子:
--
作者:
[Sasaki T., Nishihara H., Hirakawa M., Fujimura K., Tanaka M., Kokubo N., Kimura-Yoshida C., Matsuo I., Sumiyama K., Saitou N. Shimogori T., Okada N., Taguchi Y.]
通讯作者:
Taguchi Y.
共 80 条
Experimental evolutionary study of limb morphogenesis by a constitutive approach
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批准号:17K19411
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2017
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负责人:SHIROISHI Toshihiko
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依托单位:
Mutation burst by conflict of two mouse subspecies genomes
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批准号:23657009
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2011
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负责人:SHIROISHI Toshihiko
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依托单位:
Gene regulation via dynamic change of chromosomal conformation of remote enhancers
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批准号:21247002
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.62万
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财政年份:2009
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负责人:SHIROISHI Toshihiko
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依托单位:
Genetic regulation of tissue-specific Shh expression by long-range enhancers and chromosome dynamics
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批准号:19370003
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
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财政年份:2007
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负责人:SHIROISHI Toshihiko
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依托单位:
Limb bud-specific Shh enhancer that is 1Mb apart from Shh coding sequence
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批准号:17370003
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2005
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负责人:SHIROISHI Toshihiko
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依托单位:
Systematic genome function analysis based upon intersubspecific comsomic strains
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批准号:16011258
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$15.36万
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财政年份:2004
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负责人:SHIROISHI Toshihiko
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依托单位:
Research for the genetic mechanism of reproductive isolation between two mouse subspecies
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批准号:14340239
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.9万
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财政年份:2002
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负责人:SHIROISHI Toshihiko
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依托单位:
Mous Saturation mutagenesis project:Construction of sperm bank for chromosome deletion mutants and development of screening system for the mutations
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批准号:10358019
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$26.24万
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财政年份:1998
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负责人:SHIROISHI Toshihiko
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依托单位:
Positional cloning of mouse morphological mutants
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批准号:09440257
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.7万
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财政年份:1997
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负责人:SHIROISHI Toshihiko
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依托单位:
Establishment of Mouse Consomic Lines
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批准号:07558116
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$11.52万
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财政年份:1995
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负责人:SHIROISHI Toshihiko
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依托单位:
RESEARCH FOR MECHANISM OF HOMOLOGOUS CHROMOSOMAL RECOMBINATION IN MOUSE MEIOSIS
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批准号:06454006
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.54万
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财政年份:1994
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负责人:SHIROISHI Toshihiko
-
依托单位:
国内基金
海外基金
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