Research for the genetic mechanism of reproductive isolation between two mouse subspecies

两个小鼠亚种生殖隔离的遗传机制研究

基本信息

  • 批准号:
    14340239
  • 负责人:
  • 金额:
    $ 8.9万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2003
  • 项目状态:
    已结题

项目摘要

Hybrid breakdown is a type of reproductive failure that appears after the F2 generation of crosses between different species or subspecies. It is caused by incompatibility between interacting genes. Genetic analysis of hybrid breakdown, particularly in higher animals : has been hampered by its complex nature (i.e., it involves more than two genes, and the phenotype is recessive). We studied hybrid breakdown using a new consomic strain, C57BU6J-X^<MSM> in which the X chromosome of C57BL/6J (derived mostly from Mus musculus domesticus) is substituted by the X chromosome of the MSM/Ms strain (M.m.molossinus). Males of this consomic strain are sterile, whereas F_1 hybrids between C57BU6J and MSM/Ms are completely fertile. The C57BU6J-X^<MSM> males showed reduced testis weight with variable defects in spermatogenesis and abnormal sperm head morphology. We conducted quantitative trait locus (QTL) analysis for these traits to map the X-linked genetic factors responsible for the sterility. This analysis successfully detected at least three distinct loci for the sperm head morphology and one for the testis weight. This study revealed that incompatibility of interactions of X-linked gene(s) with autosomal and/or Y-linked gene(s) causes the hybrid breakdown between the genetically distant C57BL/6J and MSM/Ms strains.
杂交失败是不同物种或亚种间杂交的F2代后出现的一种繁殖失败。它是由相互作用的基因之间的不相容性引起的。杂种破坏的遗传分析,特别是在高等动物中:由于其复杂的性质(即,它涉及两个以上的基因,并且表现型是隐性的)。我们用一个新的同源品系C57 BU 6 J-X ^研究了杂种的破坏<MSM>,其中C57 BL/6 J的X染色体(主要来自小家鼠)被MSM/Ms品系(M. m. molossinus)的X染色体所取代。C57 BU 6 J与MSM/Ms的杂种F_1完全可育。C57 BU 6 J-X ^<MSM>雄性动物显示睾丸重量减轻,精子发生不同程度缺陷,精子头部形态异常。我们对这些性状进行了数量性状位点(QTL)分析,以定位与不育有关的X连锁遗传因子。该分析成功地检测到至少三个不同的位点的精子头部形态和一个睾丸重量。本研究揭示了X连锁基因与常染色体和/或Y连锁基因的相互作用的不相容性导致遗传上远缘的C57 BL/6 J和MSM/Ms株之间的杂交失败。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Oka, A.et al.: "Hybrid breakdown caused by substitution of X chromosome between two mouse subspecies"Genetics. 166. 913-924 (2004)
Oka, A. 等人:“两个小鼠亚种之间 X 染色体替换引起的杂交破坏”遗传学。
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    0
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Oka, A.et al., Hybrid Breakdown Caused by: "Substitution of X Chromosome between Two Mouse Subspecies"Genetics. 166. 913-924 (2004)
Oka, A. 等人,杂交故障引起的:“两个小鼠亚种之间 X 染色体的替换”遗传学。
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    0
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Kikkawa, Y.et al.: "Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum."Mol.Genet.. 12. 453-461 (2003)
Kikkawa, Y.等人:“一种新的支架蛋白 Sans 的突变导致杰克逊摇床小鼠耳聋。嗯。”Mol.Genet.. 12. 453-461 (2003)
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    0
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Isobe, T.et al.: "Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class II region"Genomics. 80. 229-235 (2002)
Isobe, T. 等人:“小鼠主要组织相容性复合体 II 类区域中 Pb 重组热点的分子特征”基因组学。
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    0
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Hide, T.et al.: "Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice"Development. 129. 4347-4357 (2002)
Hide, T. 等人:“Otx2 杂合突变小鼠耳头表型的遗传修饰剂”开发。
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    0
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SHIROISHI Toshihiko其他文献

KOIDE Tsuyoshi Different patterns of ultrasonic vocalizations of wild-derived mouse strains from laboratory strains.
KOIDE Tsuyoshi 野生小鼠品系与实验室品系小鼠的超声波发声模式不同。
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    SUGIMOTO Hiroki;KIKUSUI Takefumi;SHIROISHI Toshihiko
  • 通讯作者:
    SHIROISHI Toshihiko

SHIROISHI Toshihiko的其他文献

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{{ truncateString('SHIROISHI Toshihiko', 18)}}的其他基金

Experimental evolutionary study of limb morphogenesis by a constitutive approach
本构法肢体形态发生的实验进化研究
  • 批准号:
    17K19411
  • 财政年份:
    2017
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Mutation burst by conflict of two mouse subspecies genomes
两个小鼠亚种基因组冲突导致突变爆发
  • 批准号:
    23657009
  • 财政年份:
    2011
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Gene regulation via dynamic change of chromosomal conformation of remote enhancers
通过远程增强子染色体构象的动态变化进行基因调控
  • 批准号:
    21247002
  • 财政年份:
    2009
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Genetic regulation of tissue-specific Shh expression by long-range enhancers and chromosome dynamics
长程增强子和染色体动力学对组织特异性Shh表达的遗传调控
  • 批准号:
    19370003
  • 财政年份:
    2007
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional Genomics based upon mouse inter-subspecific consomic strain
基于小鼠亚种间康体菌株的功能基因组学
  • 批准号:
    17018033
  • 财政年份:
    2005
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Limb bud-specific Shh enhancer that is 1Mb apart from Shh coding sequence
肢芽特异性 Shh 增强子,距 Shh 编码序列 1Mb
  • 批准号:
    17370003
  • 财政年份:
    2005
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Systematic genome function analysis based upon intersubspecific comsomic strains
基于亚种间体株的系统基因组功能分析
  • 批准号:
    16011258
  • 财政年份:
    2004
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Mous Saturation mutagenesis project:Construction of sperm bank for chromosome deletion mutants and development of screening system for the mutations
小鼠饱和诱变项目:染色体缺失突变体精子库建设及突变筛选系统开发
  • 批准号:
    10358019
  • 财政年份:
    1998
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Positional cloning of mouse morphological mutants
小鼠形态突变体的定位克隆
  • 批准号:
    09440257
  • 财政年份:
    1997
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Establishment of Mouse Consomic Lines
小鼠体系的建立
  • 批准号:
    07558116
  • 财政年份:
    1995
  • 资助金额:
    $ 8.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)

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探讨体细胞 X 染色体改变在塑造癌症性别差异中的作用
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阐明双X染色体激活介导的女性肿瘤恶变机制
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阐明动态 X 染色体失活维持在系统性硬化症发病机制中的作用
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