Coordination Funds

协调基金

基本信息

项目摘要

In the coming years, the research field will advance beyond a simple concept of disease-associated microglia, or homeostasis-associated microglia. Sophisticated transcriptomic and transgene technologies will be combined with cutting edge in vivo imaging methods to link RNA and Protein expression profiles to distinct microglia function. In addition, analysis of big data and in silico modelling will be further employed by pre-clinical studies improving efficacy and transparency of our research activities. At the same time, bioethical aspects and quality and data management will get integrated to a greater extend into this priority program. Moreover, the current situation calls to investigate the response of microglia against viruses such as COVID-19 and its acute and long-term consequences for brain health. Therefore, it is timely to build a nation-wide, international competitive, interdisciplinary consortium and launch a priority program dedicated to investigate microglia biology.The program aims to address the following three main questions:1. Which local cues determine the microglia state? 2. How does the peripheral immune status (e.g. viral infections) modulate the microglia state and phenotype during development and ageing?3. How much of the mouse work is reflected in human diseases and how can we improve the pre-clinical models? In order to answer these questions, we need to evaluate and assimilate current data and knowledge, use cutting edge methods to visualize and manipulate microglia and integrate the peripheral-brain immune axis into our future research. Taken together, we propose the following aims and deliverables for the priority program:-Build a nation-wide database integrating OMICS, structural and functional data. -Add sex/gender as a variable into the database.-Identify local cues that shape microglia function and phenotype. -Use these data for in silico and mathematical modelling to identify therapeutic targets. -Investigate identified targets in animal models and humans.
在未来几年,研究领域将超越疾病相关小胶质细胞或稳态相关小胶质细胞的简单概念。先进的转录组学和转基因技术将与尖端的体内成像方法相结合,将RNA和蛋白质表达谱与不同的小胶质细胞功能联系起来。此外,临床前研究将进一步采用大数据分析和计算机建模,以提高我们研究活动的有效性和透明度。与此同时,生物伦理方面以及质量和数据管理将更大程度地纳入这一优先方案。此外,目前的情况要求研究小胶质细胞对COVID-19等病毒的反应及其对大脑健康的急性和长期后果。因此,建立一个全国性的、具有国际竞争力的、跨学科的联合体,启动一个致力于小胶质细胞生物学研究的优先项目是非常及时的。 哪些局部线索决定了小胶质细胞的状态?2. 外周免疫状态(例如病毒感染)如何调节发育和衰老过程中小胶质细胞的状态和表型?3. 小鼠的工作有多少反映在人类疾病中?我们如何改进临床前模型? 为了回答这些问题,我们需要评估和吸收现有的数据和知识,使用尖端的方法来可视化和操纵小胶质细胞,并将外周脑免疫轴整合到我们未来的研究中。综上所述,我们提出了以下目标和交付的优先方案:-建立一个全国性的数据库,集成OMICS,结构和功能数据。- 将性别/性别作为变量添加到数据库中。识别塑造小胶质细胞功能和表型的局部线索。- 使用这些数据进行计算机模拟和数学建模,以确定治疗靶点。- 研究动物模型和人类中确定的目标。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Privatdozentin Dr. Susanne A. Wolf其他文献

Privatdozentin Dr. Susanne A. Wolf的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Privatdozentin Dr. Susanne A. Wolf', 18)}}的其他基金

Microglia/Myeloid System in Anxiety and Depression
焦虑和抑郁中的小胶质细胞/骨髓系统
  • 批准号:
    407530837
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Investigating the impact of cellular senescence of neuronal progenitor cells and microglia on cellular functionality and behavior
研究神经祖细胞和小胶质细胞的细胞衰老对细胞功能和行为的影响
  • 批准号:
    269902361
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Grants

相似海外基金

Coordination Funds
协调基金
  • 批准号:
    436278370
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    422443988
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    423033110
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    424702474
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    427459213
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Priority Programmes
Coordination Funds
协调基金
  • 批准号:
    427358138
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    428795801
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    426581255
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Clinical Research Units
Coordination Funds
协调基金
  • 批准号:
    428918039
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
Coordination Funds
协调基金
  • 批准号:
    416092893
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Units
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了