Basic and applied genomics of enterohemorrhagic Escherichia coli and related enteropathogens

通过对肠出血性大肠杆菌（EHEC）及相关肠病原体进行一系列基因组测序和功能分析。我们成功建立了O157 EHEC快速分型系统，获得了三种主要非O157 EHEC的全基因组序列，提高了我们对这些病原体III型分泌机制和其他毒力系统的功能和进化机制的认识。此外，通过比较宏基因组分析，我们成功地阐明了成人和婴儿肠道微生物群的遗传和功能差异，并获得了3种细菌（4株，包括一种不可培养细菌）的全基因组序列。

By performing a series of genome sequencing and functional analyses of enterohemorrhagic Ecsherichia coli (EHEC) and related enteropathogens. we succeeded in developing a rapid O157 EHEC strain typing system, obtaining the complete genome sequences of three major non-O157 EHECs, and improving our understanding of functions and evolution mechanisms of type III secretion mechanisms and other virulence systems of these pathogens. In addition, we succeeded in clarifying the genetic and functional differences of adult and infant gut microbiota by comparative metagenomic analysis and obtaining the complete genome sequences of 3 bacterial species (4 strains, including an unculturable bacterium) residing in intestine.