Biomechanical force-sensing and response mechanisms in vascular cells and its application to tissue engineering
血管细胞的生物力学力传感和响应机制及其在组织工程中的应用
基本信息
- 批准号:17076002
- 负责人:
- 金额:$ 63.04万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas
- 财政年份:2005
- 资助国家:日本
- 起止时间:2005 至 2009
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Embryonic stem cells (ES cells) are attracting interests as a promising source of cells for use in regenerative medicine. The aim of the present study was to investigate whether biomechanical forces such as shear stress and cyclic strain affect ES cell differentiation. Fluid shear stress induced differentiation of cultured murine ES cell-derived VEGF receptor 2-positive (VEGFR2^+) cells into endothelial cells (ECs), whereas cyclic strain promoted the differentiation of the cells into smooth muscle cells (SMCs). Thus, it seems likely that biomechanical forces act as key regulators of early vascular development in the embryo. Moreover, biomechanical force may provide an invaluable tool to directly control ES cell differentiation in the field of tissue engineering.
胚胎干细胞(ES细胞)作为再生医学中有前途的细胞来源正在引起人们的兴趣。本研究的目的是调查是否生物力学力,如剪切应力和循环应变影响ES细胞分化。流体切应力可诱导培养的小鼠ES细胞来源的VEGF受体2阳性(VEGFR2^+)细胞分化为内皮细胞(EC),而循环应变可促进细胞分化为平滑肌细胞(SMC)。因此,生物力学力似乎是胚胎早期血管发育的关键调节因子。此外,在组织工程领域中,生物力学力可能为直接控制ES细胞分化提供一种宝贵的工具。
项目成果
期刊论文数量(87)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
流れ勇断応力はVEGF-Notchシグナルを介して血管内皮前駆細胞を動脈化する
流动应力通过 VEGF-Notch 信号使血管内皮祖细胞动脉化
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:桝村智美、山本希美子;他3名
- 通讯作者:他3名
Cyclic strain induces ES cell differentiation into vascular smooth muscle cell via PDGF receptor b activation
循环菌株通过PDGF受体b激活诱导ES细胞分化为血管平滑肌细胞
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:K.Yamamoto;N. Shimizu;S. Ob i and J. Ando
- 通讯作者:S. Ob i and J. Ando
The role of endothelial P2X4 receptors in flow-dependent control of vascular tone and remodeling.
内皮 P2X4 受体在血管张力和重塑的血流依赖性控制中的作用。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:J. Ando;K. Yamamoto;T. Sokabe;A. Kamiya
- 通讯作者:A. Kamiya
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{{ truncateString('ANDO Joji', 18)}}的其他基金
Molecular Biomechanics of Vascular Cell Mechano-Responses
血管细胞机械反应的分子生物力学
- 批准号:
21220011 - 财政年份:2009
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
Ion channel-mediated blood flow-sensing mechanism in vascular endothelial cells
血管内皮细胞离子通道介导的血流传感机制
- 批准号:
18200030 - 财政年份:2006
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Mechano-sensing Mechanism and Mechano-Responsive Genes in Vascular Endothelial Cells
血管内皮细胞的机械感应机制和机械响应基因
- 批准号:
15200034 - 财政年份:2003
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Exploration of blood flow-sensing molecules in vascular endothelial cells
血管内皮细胞血流传感分子的探索
- 批准号:
13308052 - 财政年份:2001
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Elucidation of the mechanism of vascular cell sensing and gene responses to mechanical stresses
阐明血管细胞感知和基因对机械应力的反应机制
- 批准号:
11308035 - 财政年份:1999
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for Scientific Research (A).
Cloning of shear stress-sensitive endothelial genes
剪切应力敏感内皮基因的克隆
- 批准号:
08408039 - 财政年份:1996
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
A Bio-Engineering Research on the Sensing and Responding Mechanism of Vascular Endothelial Cells to Blood Flow
血管内皮细胞对血流感知与响应机制的生物工程研究
- 批准号:
05454692 - 财政年份:1993
- 资助金额:
$ 63.04万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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