ヒトの視覚認知の脳内機構に関する精神物理・神経心理学的研究

人类视觉认知的脑机制的心理物理学和神经心理学研究

• 批准号: 18020003
• 负责人: 森 悦朗
• 金额: $ 4.1万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18020003/
• 关键词: パーキンソン病; 高次視知覚; 視覚認知障害; PET; 視知覚; ポジトロン断層撮影; 神経心理学; 視覚認知; フルオログルコース

パーキンソン病(PD)では,後方脳領域と関連した高次視知覚障害や視覚認知障害が存在し,PDに高頻度に出現する錯視や幻視に関与している可能性がある.そこで,痴呆を伴わないPD患者にて高次視知覚と錯綜図認知が障害されているかを検証し,FDG-PETを用いた安静時局所脳糖代謝との相関をもとにそれらの障害の脳内基盤を検討した.対象はPD患者41例と,年齢,教育年数を統制した健常対照群(NC)20例.1.高次視知覚課題:標的刺激を画面に提示,標的刺激の位置や標的刺激がつくる形を二択で答えさせた.解答の正誤に基づき刺激提示時間を制御した.40試行実施し,最後の5試行の平均提示時間を標的刺激の知覚閾値とした.2.錯綜図課題:4つの線画を重ね描きした刺激を提示し同定させた.成績は,提示されたものを同定できた数(正答数)と不提示のものを誤って報告した数(誤答数)を測定した.FDG-PETで安静時の局所脳糖代謝を測定し,SPM5を用いて各視覚課題の成績と脳糖代謝が相関した領域を解析した.その結果,1.高次視知覚課題:PD群は,NC群と比較して交叉の有無の形と,Kanizsa型主観的輪郭刺激に対してのみ知覚に要する時間が有意に延長していた(p<.05).交叉・形の成績と負の相関を示す局所脳糖代謝領域は,右下側頭後頭接合部領域,左中側頭後方領域であった.また,Kanizsa型の成績とは,両下側頭後頭接合部領域,左下頭頂小葉領域の脳糖代謝が負の相関を認めた.2.錯綜図課題:PD群とNC群との間に正答数では差がなかったが,誤答数がPD群にて多かった(p<.05).誤答数は,両側の下側頭葉,側頭頭頂後頭接合部領域の脳糖代謝が負の相関を示した.痴呆を伴わないPDにおいて高次視覚領域の脳糖代謝と関連した視覚認知障害を呈していることが明らかとなった.

パーキンソン Disease (PD)では, the connection between the rear and the field of vision, the high frequency of visual cognitive impairment, the existence of cognitive impairment, and the high frequency of PD The degree of occurrence of hallucinations and hallucinations are related to the possibility of hallucinations and the possibility of dementia and the high-level vision of PD patients. Intricate cognitive impairment and cognitive impairment, FDG-PET use and calmness, glucose metabolism and related factors 41 cases of PD patients were diagnosed with the disease, age, education, control, health, and control group (NC). ) 20 Examples. 1. High-level visual perception task: the target stimulus is the picture prompt, the target stimulus is the location, the target stimulus is the shape and the answer isえさせた.Answer のCorrect or Falseにbasedづきstimulating prompt timeをcontrolした.40 trial trial implementationし,last の5 trial trial average prompt timeをThe target stimulus is the threshold value. 2. Intricate topic: 4 Line drawing is heavy and the stimulus is the prompt. The result is the same. , the number of the same number (the number of correct answers) that prompts the same number (the number of correct answers) and the number of the wrong answers (the number of incorrect answers) that does not prompt the number of reports (the number of incorrect answers) and the number of errors that are not prompted are measured. FD G-PET is used for the determination of glucose metabolism at rest, and SPM5 is used to determine the results of each subject and to determine the correlation between glucose metabolism and glucose metabolism. Domain analysis results, 1. High-order visual knowledge topic: PD group, NC group comparison, intersection, presence or absence, Kani The zsa type main body is stimulated and stimulated by knowing the time and length of time (p<.05). Cross and shape The results show a negative correlation in the glycometabolism domain, the lower right cephalad joint domain, and the middle left cephalad domain. Kanizsa-type results are negative, and there is a negative correlation between sugar metabolism in the lower lateral craniocerebral junction area and the left lower parietal lobule area. .2. Intricate topics: PD group and NC group, the number of correct answers is the same, the number of incorrect answers is the same as the PD group (p <.05). The number of incorrect answers is negative, and there is a negative correlation between sugar metabolism in the lower lateral cephalic lobe and the posterior cephalic junction area. Dementia. The high-order visual field of PD is related to glucose metabolism and cognitive impairment.

项目成果

Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus

• DOI: 10.1159/000119521
• 发表时间: 2008-01-01
• 期刊: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
• 影响因子: 2.4
• 作者: Ishii, Kazunari;Kawaguchi, Tetsuro;Mori, Etsuro
• 通讯作者: Mori, Etsuro

Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei

脑干多巴胺能核损伤后的额叶综合征和精神病

• 发表时间: 2007
• 期刊: J Neurol Sci 260(1-2)
• 作者: Nishio Y;Ishii K;Kazui H;Hosokai Y;Mori E
• 通讯作者: Mori E

Actions anchored by concepts: defective action comprehension in semantic dementia

以概念为基础的行动：语义痴呆症的行动理解缺陷

• 发表时间: 2006
• 期刊: J Neurol Neurosurg Psychiatry 77
• 作者: Nishio Y;Kazui H;Hashimoto M;Shimizu K;Onouchi K;Mochio S;Suzuki K;Mori E
• 通讯作者: Mori E

Selective impairment in the retrieval of family relationships in person identification: A case study of delusional misidentification

• DOI: 10.1016/j.neuropsychologia.2007.06.003
• 发表时间: 2007-01-01
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Abe, Nobuhito;Ishii, Hiroshi;Mori, Etsuro
• 通讯作者: Mori, Etsuro

Deceiving others: Distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions

• DOI: 10.1162/jocn.2007.19.2.287
• 发表时间: 2007-02-01
• 期刊: JOURNAL OF COGNITIVE NEUROSCIENCE
• 影响因子: 3.2
• 作者: Abe, Nobuhito;Suzuki, Maki;Fujii, Toshikatsu
• 通讯作者: Fujii, Toshikatsu