Spectrometer for Dynamic Nuclear Polarization-NMR

应用DNP单元(动态核极化)和光谱仪控制台，对现有的400 MHz固态光谱仪进行扩展，以提高信号强度(提高10到40倍)，从而大大缩短核磁共振固态光谱的测量时间。它用于生物材料、催化剂和蛋白质等固体的分子结构研究。然而，它的特点是自然灵敏度低，相关的测量时间长达数天。申请的DNP装置是一个微波源(回旋管)，通过它，位于核磁共振磁体中的样品被微波(263 GHz)照射，允许样品中未配对的电子自旋被极化。电子和原子核之间的相互作用使电子极化转移到原子核，核磁共振信号被放大两到三个数量级。通过增强核磁共振信号，DNP-核磁共振波谱使具有许多不同功能单元的非常复杂的结构的结构阐明以及对具有低浓度天然活性中心的材料的研究成为可能。在碳源和转化主席，将使用这种分析方法研究含碳生物聚合物(如木质素)、多相催化剂上的表面物种以及含碳原料(如塑料回收的碳化产物)和碳基产品(如石墨烯)。通过阐明潜在的化学结构，可以开发和优化这些材料的使用、转化和生产的新工艺。在其他工作组(利用率份额10%)中，对蛋白质和多肽、纳米载体和抗菌活性分子、金属-有机设备化合物、碳载体催化剂和纳米碳材料的结构阐明的扩展分析方法特别令人感兴趣。拟议的带有控制台的DNP单位将与中央核磁共振设施RUBiospek|核磁共振中现有的400 MHz核磁共振磁体一起建立，从而可以使用既定的组织结构和空间基础设施。核磁共振光谱仪的集中使用在过去几十年中已经证明了自己，并使感兴趣的团体能够轻松获得设备。由于动态核极化能够大幅缩短测量时间，在拟议的DNP装置的帮助下，可以处理额外的样品体积，并提供扩展的分析选项，尽管现有的固态核磁共振光谱仪得到了充分利用。

The application is for a DNP unit (Dynamic Nuclear Polarization) and spectrometer console to expand an existing 400 MHz solid-state spectrometer to increase the signal intensity (by a factor of 10 to 40) and thus drastically shorten the measurement times of NMR solid state spectroscopy. This is used for the molecular structure elucidation of solids, such as biomaterials, catalysts and proteins. However, it is characterized by low natural sensitivity and the associated long measurement times of up to several days. The DNP unit applied for is a microwave source (gyrotron) through which a sample located in the NMR magnet is irradiated with microwaves (263 GHz), allowing unpaired electron spins in the sample to be polarized. Interactions between electrons and atomic nuclei allow the electron polarization to be transferred to the nuclei and the nuclear magnetic resonance signal is amplified by two to three orders of magnitude. By intensifying the NMR signals, DNP-NMR spectroscopy enables the structural elucidation of very complex structures with many different functional units as well as the investigation of materials that have a low concentration of natural active centers. At the Chair of Carbon Sources and Conversion, carbon-containing biopolymers (e.g. lignin), surface species on heterogeneous catalysts as well as carbon-containing starting materials (e.g. carbonization products from the recycling of plastics) and carbon-based products (e.g. graphene) are to be investigated using this analytical method. By elucidating the underlying chemical structures, new processes for the use, conversion and production of these materials can be developed and optimized. In the other working groups (utilization share > 10%), the extended analysis method for the structure elucidation of proteins and peptides, of nanocarriers and antibacterial active molecules, of metal-organic equipment compounds, carbon-supported catalysts and nanoscale carbon materials is of extraordinary interest. The proposed DNP unit with control console is to be set up with the existing 400 MHz NMR magnet in the central NMR facility RUBiospek|NMR, whereby established organizational structures as well as the spatial infrastructure can be used. The centralized use of NMR spectrometers has proven itself over the past decades and allows interested groups easy access to the equipment. Since dynamic nuclear polarization enables a drastic reduction in measurement times, it is possible with the help of the proposed DNP unit to process an additional sample volume and offer extended analysis options despite the existing full utilization of the existing solid-state NMR spectrometer.