Creation of Natural-Artificial Molecules Conjugates for Development of Novel non-Natural Function
Creation of Natural-Artificial Molecules Conjugates for Development of Novel non-Natural Function
批准号:
18065012
负责人:
NAKAJIMA Hiroshi
金额:
$20.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2009
中文摘要
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英文摘要
A goal of the present study is to establish novel technologies of protein engineering that are distinguishable from conventional modification methods such as site directed mutagenesis. Achievements are summarized as followings : (1) Creation of organometallic proteins bearing artificial metal complexes, and development of their catalytic reactions, (2) Creation of signal transduction system consisting of electron transfer proteins and an environment responsive polymer, (3) Application of proteins from thermophiles to construct robust artificial proteins amenable to future practical uses. The achievements of the present work will contribute to further development of the protein engineering in both basic and practical aspects.
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シトクロムP450BSβによる非天然基質の触媒的酸化反応とデコイ分子の構造との関連
细胞色素P450BSβ催化非天然底物的氧化反应及其与诱饵分子结构的关系
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[藤城貴史, 中島 洋, 渡辺芳人]
通讯作者:
渡辺芳人
デコイ分子によるヘム酵素の基質選択性の変換
诱饵分子改变血红素酶底物选择性
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[藤城貴史, 中島 洋, 渡辺芳人]
通讯作者:
渡辺芳人
DOI:
10.1039/b924365h
发表时间:
2010-01-01
期刊:
DALTON TRANSACTIONS
影响因子:
4
作者:
[Nakajima, Hiroshi, Ramanathan, Kalaivani, Watanabe, Yoshihito]
通讯作者:
Watanabe, Yoshihito
Engineering of Thermally Tolerant Protein from Thermphiles like Thermus Thermophilus
来自嗜热菌(如嗜热栖热菌)的耐热蛋白的工程
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[R.Kalaivani, N.Kawaba, H.Nakaiima, Y.Watanabe]
通讯作者:
Y.Watanabe
Single protein based photo-switching device constituted with zinc cytochrome c and HOOC-SAM electrode
由锌细胞色素c和HOOC-SAM电极构成的基于单蛋白的光开关器件
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Takao Ikariya, A.John Blacker, H.Nakajima]
通讯作者:
H.Nakajima
共 54 条
The Criminal Procedure and the Person with Mental Disorders or Intellectual Disabilities
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批准号:15K03178
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.08万
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财政年份:2015
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负责人:NAKAJIMA Hiroshi
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依托单位:
Construction of a porphyrin capsule applicable to a photodynamic therapy
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批准号:25620130
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2013
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负责人:NAKAJIMA Hiroshi
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依托单位:
Reduction of memory Th2 cell pool for the treatment of allergic diseases
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批准号:23659496
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:NAKAJIMA Hiroshi
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依托单位:
Development of Mixed Analog ASIC for High-Speed Low-Noise Signal Processing of X-ray CCDs
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批准号:22740122
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2010
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负责人:NAKAJIMA Hiroshi
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依托单位:
A novel biosensing mechanism using sensor kinase activity
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批准号:22550149
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2010
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负责人:NAKAJIMA Hiroshi
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依托单位:
Empirical Study of Victims' Participation in Criminal Trials
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批准号:21530067
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.33万
-
财政年份:2009
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负责人:NAKAJIMA Hiroshi
-
依托单位:
Analysis of helper T cell subset in severe asthma for the development of new immunotherapy
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批准号:21390255
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2009
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负责人:NAKAJIMA Hiroshi
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依托单位:
Basic study on development of cements used for fixing implant superstructure on abutment.
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批准号:20592308
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2008
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负责人:NAKAJIMA Hiroshi
-
依托单位:
Role of IL-17 family cytokines in severe asthma
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批准号:19591156
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:NAKAJIMA Hiroshi
-
依托单位:
Engineering of proteins from thermophilic bacteria as a scaffold for thermally tolerant artificial enzyme
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批准号:18560753
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.51万
-
财政年份:2006
-
负责人:NAKAJIMA Hiroshi
-
依托单位:
Mechanisms underlying IL-4-induced IFN-γ production in plasmacytoid dendritic cells
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批准号:17591029
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:NAKAJIMA Hiroshi
-
依托单位:
Characterization of Stat6 protease and Stat5 protease
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批准号:15591046
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2003
-
负责人:NAKAJIMA Hiroshi
-
依托单位:
Study on factors affecting the failure, deformation and adhesive durability of fluoride-releasing restorative materials
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批准号:12671899
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:2000
-
负责人:NAKAJIMA Hiroshi
-
依托单位:
Observations of Temporal Fine Structures in Solar Millimeterwave Bursts
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批准号:02640208
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1990
-
负责人:NAKAJIMA Hiroshi
-
依托单位:
Studies of Clinical Diagnosis and Treatment on Cutaneous T-Cell Lymphoma
-
批准号:63570473
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1988
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负责人:NAKAJIMA Hiroshi
-
依托单位:
Correlator LSI Chips Made on an Experimental Basis
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批准号:62840002
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$5.5万
-
财政年份:1987
-
负责人:NAKAJIMA Hiroshi
-
依托单位: