A novel biosensing mechanism using sensor kinase activity
A novel biosensing mechanism using sensor kinase activity
批准号:
22550149
负责人:
NAKAJIMA Hiroshi
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The objective of this study is to produce a novel bio-sensing mechanism constituted by sensor-kinase and signal transduction system that we proposed in previous works. Sensor-kinase is a protein which senses an external stimulus such as a simple molecule or light to phosphorylate a particular protein and regulate its activity. In this study, we attempted to transform the output of sensor-kinase to an electronic signal. We have almost achieved the initial objective by using a transcriptional regulator in place of sensor-kinase as a sensory moiety.
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发表时间:
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DOI:
10.1021/bi201048e
发表时间:
2011-11-15
期刊:
BIOCHEMISTRY
影响因子:
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