Development of tumor-specific immunotherapy based on the analysis of functions of dendritic cells

基于树突状细胞功能分析开发肿瘤特异性免疫治疗

• 批准号: 20015016
• 负责人: TAHARA Hideaki
• 金额: $ 9.98万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20015016/
• 关键词: 免疫学; がん治療; 樹状細胞; サイトカイン; 遺伝子治療

Dendritic cells (DCs) are the immune cells which direct the immune responses of the host. It has been conceived that the examination on the DCs could lead to the development of effective immunological therapy against cancer. In this project, we have found using mouse tumor systems that systemic administration of IL-23, a cytokine secreted by DCs, and blocking antibody against Milk Fat Globule EGF-8(MFG-E8) could be effective cancer immunotherapy.

树突状细胞（Dendritic cells，DC）是指导宿主免疫应答的免疫细胞。人们认为，对树突状细胞的检测可能会导致有效的免疫治疗癌症的发展。在这个项目中，我们已经发现使用小鼠肿瘤系统，全身施用IL-23（由DC分泌的细胞因子）和针对乳脂肪球EGF-8（MFG-E8）的阻断抗体可以是有效的癌症免疫疗法。

项目成果

Milk Fat Globule EGF-8 blockade triggers tumor destruction through coor dinated cell-autonomous and immune-mediated mechanisms

乳脂肪球 EGF-8 阻断通过协调细胞自主和免疫介导机制触发肿瘤破坏

• 发表时间: 2009
• 期刊: Journal of Experimental Medicine 100
• 作者: Jinushi M;Sato M;Kanamoto A;Itoh A;Nagai S;Koyasu S;Dranoff G;Tahara H.
• 通讯作者: Tahara H.

Antigen-specific antitumor effects of DNA vaccine are significantly enhanced with systemic administration of interleukin(IL)-23

全身注射白细胞介素 (IL)-23 可显着增强 DNA 疫苗的抗原特异性抗肿瘤作用

• 发表时间: 2009
• 作者: 米山公康、田原秀晃;他3名
• 通讯作者: 他3名

Potent Anti-tumor Immunity and both Th1 and Th17 promotion associated with IL-23 administration (Symposium) Annual Meeting

与 IL-23 给药相关的强效抗肿瘤免疫以及 Th1 和 Th17 促进（研讨会）年会

• 发表时间: 2008
• 作者: Du YC;Minamoto T;et al.;西田千恵美;Hideaki Tahara
• 通讯作者: Hideaki Tahara

Induction of and-tumor immune response by homeostatic prolifer ation and CD28 sianalina

通过稳态增殖和 CD28 唾液酸诱导肿瘤免疫反应

• 发表时间: 2008
• 期刊: J Immunology 180
• 作者: Suzuki T;Ogawa S;Tanabe K;Tahara H. Abe R.Kishimoto H
• 通讯作者: Tahara H. Abe R.Kishimoto H

Emerging concepts in biomarker discovery.

生物标志物发现中的新兴概念。

• 发表时间: 2009
• 期刊: the US-Japan Workshop on Immunological Molecular Markers in Oncology.J Transl Med. 7
• 作者: Tahara H.;et al.
• 通讯作者: et al.