Development of tumor-specific immunotherapy based on the analysis of functions of dendritic cells
Development of tumor-specific immunotherapy based on the analysis of functions of dendritic cells
批准号:
20015016
负责人:
TAHARA Hideaki
金额:
$9.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Dendritic cells (DCs) are the immune cells which direct the immune responses of the host. It has been conceived that the examination on the DCs could lead to the development of effective immunological therapy against cancer. In this project, we have found using mouse tumor systems that systemic administration of IL-23, a cytokine secreted by DCs, and blocking antibody against Milk Fat Globule EGF-8(MFG-E8) could be effective cancer immunotherapy.
期刊论文(19)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Milk Fat Globule EGF-8 blockade triggers tumor destruction through coor dinated cell-autonomous and immune-mediated mechanisms
乳脂肪球 EGF-8 阻断通过协调细胞自主和免疫介导机制触发肿瘤破坏
DOI:
--
发表时间:
2009
期刊:
Journal of Experimental Medicine 100
影响因子:
--
作者:
[Jinushi M, Sato M, Kanamoto A, Itoh A, Nagai S, Koyasu S, Dranoff G, Tahara H.]
通讯作者:
Tahara H.
Antigen-specific antitumor effects of DNA vaccine are significantly enhanced with systemic administration of interleukin(IL)-23
全身注射白细胞介素 (IL)-23 可显着增强 DNA 疫苗的抗原特异性抗肿瘤作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[米山公康、田原秀晃, 他3名]
通讯作者:
他3名
Induction of and-tumor immune response by homeostatic prolifer ation and CD28 sianalina
通过稳态增殖和 CD28 唾液酸诱导肿瘤免疫反应
DOI:
--
发表时间:
2008
期刊:
J Immunology 180
影响因子:
--
作者:
[Suzuki T, Ogawa S, Tanabe K, Tahara H. Abe R.Kishimoto H]
通讯作者:
Tahara H. Abe R.Kishimoto H
Potent Anti-tumor Immunity and both Th1 and Th17 promotion associated with IL-23 administration (Symposium) Annual Meeting
与 IL-23 给药相关的强效抗肿瘤免疫以及 Th1 和 Th17 促进(研讨会)年会
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Du YC, Minamoto T, et al., 西田千恵美, Hideaki Tahara]
通讯作者:
Hideaki Tahara
Emerging concepts in biomarker discovery.
生物标志物发现中的新兴概念。
DOI:
--
发表时间:
2009
期刊:
the US-Japan Workshop on Immunological Molecular Markers in Oncology.J Transl Med. 7
影响因子:
--
作者:
[Tahara H., et al.]
通讯作者:
et al.
共 13 条
Preclinical Development of Cellular Gene therapy using Viral Vector
-
批准号:21249069
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$30.04万
-
财政年份:2009
-
负责人:TAHARA Hideaki
-
依托单位:
Development of cancer immune-gene therapy using viral vector produced in Japanese academia
-
批准号:17209042
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$30.45万
-
财政年份:2005
-
负责人:TAHARA Hideaki
-
依托单位:
Clinical development of cancer gene therapy using viral vectors
-
批准号:14207047
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$29.37万
-
财政年份:2002
-
负责人:TAHARA Hideaki
-
依托单位:
Adjuvant immuno-gene therapy for surgical treatment using dendritic cells
-
批准号:12470237
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
-
财政年份:2000
-
负责人:TAHARA Hideaki
-
依托单位:
海外基金