Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptides

阐明宿主免疫细胞杀死原生动物寄生虫的机制并开发抗寄生虫肽

• 批准号: 15K20840
• 负责人: Terkawi Alaa
• 金额: $ 2.66万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K20840/
• 关键词: Macrophages; Neutrophils; Phagocytes; Effector molecules; neutrophils; effector molecules; DNA Microarray; DEFB130; CTSL

项目成果

Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.

• DOI: 10.1371/journal.pone.0125276
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Rizk MA;El-Sayed SA;Terkawi MA;Youssef MA;El Said el Sel S;Elsayed G;El-Khodery S;El-Ashker M;Elsify A;Omar M;Salama A;Yokoyama N;Igarashi I
• 通讯作者: Igarashi I

Isolation and co-cultivation of human macrophages and neutrophils with Plasmodium falciparum-parasitized erythrocytes: An optimized system to study the phagocytic activity to malarial parasites

人类巨噬细胞和中性粒细胞与恶性疟原虫寄生红细胞的分离和共培养：研究疟疾寄生虫吞噬活性的优化系统

• DOI: 10.1016/j.parint.2016.03.005
• 发表时间: 2016
• 期刊: Parasitology International
• 影响因子: 1.9
• 作者: Terkawi MA;Takano;R;Kato K.
• 通讯作者: Kato K.

Molecular detection and characterization of Babesia bovis, Babesia bigemina, Theileria species and Anaplasma marginale isolated from cattle in Kenya.

• DOI: 10.1186/s13071-015-1106-9
• 发表时间: 2015-09-30
• 期刊: Parasites & vectors
• 影响因子: 3.2
• 作者: Adjou Moumouni PF;Aboge GO;Terkawi MA;Masatani T;Cao S;Kamyingkird K;Jirapattharasate C;Zhou M;Wang G;Liu M;Iguchi A;Vudriko P;Ybanez AP;Inokuma H;Shirafuji-Umemiya R;Suzuki H;Xuan X
• 通讯作者: Xuan X

Differentiated gene profile of neutrophils induced by phagocytosis of Plasmodium falciparum-parasitized erythrocytes.

恶性疟原虫寄生红细胞的吞噬作用诱导的中性粒细胞的分化基因谱。

• 发表时间: 2016
• 作者: Terkawi MA;Takano T;Kato K.;Terkawi MA
• 通讯作者: Terkawi MA

Characterization of Toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures.

• DOI: 10.1186/s13071-015-1268-5
• 发表时间: 2015-12-23
• 期刊: Parasites & vectors
• 影响因子: 3.2
• 作者: Goo YK;Yamagishi J;Ueno A;Terkawi MA;Aboge GO;Kwak D;Hong Y;Chung DI;Igarashi M;Nishikawa Y;Xuan X
• 通讯作者: Xuan X