Development of novel therapeutic intervention for controlling inflammatory osteolysis leading to total hip arthroplasty

开发新的治疗干预措施来控制导致全髋关节置换术的炎症性骨溶解

• 批准号: 17K10993
• 负责人: Terkawi Alaa
• 金额: $ 2.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10993/
• 关键词: 人工股関節置換術後の無菌性緩み; マクロファージ; サイトカイン; ケモカイン; 人工関節置換術後の無菌性緩み; 炎症性骨溶解; 破骨細胞; IL-27; Osteolysis; Inflammation; Osteoclastogenesis; Bone resorption; 骨融解; 炎症反応; インプラント

项目成果

Gene profiling of macrophages stimulated with vitamin E-blended polyethylene orthopedic implants debris identifies IL-27 as potent regulator of osteolysis

用维生素 E 混合聚乙烯骨科植入物碎片刺激巨噬细胞的基因分析表明 IL-27 是骨溶解的有效调节剂

• 发表时间: 2018
• 作者: Fereig Ragab M.;Kuroda Yasuhiro;Terkawi Mohamad Alaa;Mahmoud Motamed Elsayed;Nishikawa Yoshifumi;Hend Alhasan;Gen Matsumae;Gen Matsumae;Alaa Terkawi;M Alaa Terkawi;M Alaa Terkawi
• 通讯作者: M Alaa Terkawi

Effects of Ultra-Purified Alginate Gel Implantation on Meniscal Defects in Rabbits

• DOI: 10.1177/0363546518816690
• 发表时间: 2019-03-01
• 期刊: AMERICAN JOURNAL OF SPORTS MEDICINE
• 影响因子: 4.8
• 作者: Kim, WooYoung;Onodera, Tomohiro;Iwasaki, Norimasa
• 通讯作者: Iwasaki, Norimasa

A mathematical model for predicting postoperative leg shortening after curved intertrochanteric varus osteotomy for osteonecrosis of the femoral head

股骨头坏死弯曲转子间内翻截骨术后下肢缩短预测的数学模型

• DOI: 10.1371/journal.pone.0208818
• 发表时间: 2018
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Asano Tsuyoshi;Takahashi Daisuke;Shimizu Tomohiro;Irie Tohru;Arai Ryuta;Terkawi Mohamad Alaa;Iwasaki Norimasa
• 通讯作者: Iwasaki Norimasa

Neutrophils-derived annexin A1 is a potential regulator of inflammatory osteolysis triggered by polyethylene wear debris of orthopedic implants

中性粒细胞衍生的膜联蛋白 A1 是骨科植入物聚乙烯磨损碎片引发的炎症性骨溶解的潜在调节剂

• 发表时间: 2020
• 作者: Fereig Ragab M.;Kuroda Yasuhiro;Terkawi Mohamad Alaa;Mahmoud Motamed Elsayed;Nishikawa Yoshifumi;Hend Alhasan
• 通讯作者: Hend Alhasan

Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants reveals a novel mechanism of osteolysis

骨科植入物超高分子量聚乙烯颗粒碎片刺激的人类巨噬细胞的转录谱揭示了一种新的骨溶解机制

• 发表时间: 2018
• 作者: Terkawi MA;Hamasaki M;Ota M;Takahashi D;Alhasan H;Iwasaki N.
• 通讯作者: Iwasaki N.