Investigation of spatial resolution improvement by use of mouth-insert detector in the helmet PET

头盔PET中使用口插入式探测器提高空间分辨率的研究

• 批准号: 16K19241
• 负责人: Ahmed Abdella
• 金额: $ 2.5万
• 依托单位: National Institutes for Quantum and Radiological Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K19241/
• 关键词: PET; radiation detector; image reconstruction; Computing

The dominant factor that limits the intrinsic spatial resolution of a PET system is the size of the crystal elements in the detector. To increase the sensitivity and achieve high spatial resolution, it is essential to use advanced depth-of-interaction (DOI) detectors and arrange them close to the subject. The DOI detectors help to maintain high spatial resolution by mitigating the parallax error caused by the thickness of the scintillator at the peripheral regions in the field-of-view. As an optimal geometry for a brain PET scanner with high sensitivity and high spatial resolution, we proposed and developed the helmet-chin PET using 54 4-layered DOI detectors consisting of 16×16×4 array of GSOZ scintillator crystals with dimensions of 2.8×2.8×7.5 mm3. All the detectors used in the helmet-chin PET had the same spatial resolution. In this study, we conducted a feasibility simulation of a new add-on detector arrangement for the helmet PET by replacing the chin detector with a segmented crystal cube, having high spatial resolution in all directions, which can be placed inside the mouth. The crystal cube (which we call the mouth-insert detector) has 20×20×20 LYSO crystal segments with dimensions of 1×1×1 mm3. Thus, the scanner is formed by the combination of the helmet and mouth-insert detectors, and is referred to as the helmet-mouth-insert PET. The results show that the sensitivity of the helmet-mouth-insert PET had a comparable sensitivity and an improved spatial resolution near the center of the hemisphere compared to those of the helmet chin PET.

限制 PET 系统固有空间分辨率的主要因素是探测器中晶体元件的尺寸。为了提高灵敏度并实现高空间分辨率，必须使用先进的交互深度 (DOI) 探测器并将其放置在靠近主体的位置。 DOI 探测器通过减轻视场外围区域闪烁体厚度引起的视差来帮助保持高空间分辨率。作为高灵敏度和高空间分辨率的脑 PET 扫描仪的最佳几何结构，我们提出并开发了头盔下巴 PET，使用 54 个 4 层 DOI 探测器，由 16×16×4 阵列的 GSOZ 闪烁体晶体组成，尺寸为 2.8×2.8×7.5 mm3。头盔下巴 PET 中使用的所有探测器都具有相同的空间分辨率。在这项研究中，我们对头盔 PET 的新型附加探测器布置进行了可行性模拟，用分段晶体立方体代替下巴探测器，该晶体立方体在各个方向上都具有高空间分辨率，可以放置在嘴内。晶体立方体（我们称之为口插入探测器）有20×20×20个LYSO晶体片，尺寸为1×1×1 mm3。因此，该扫描仪由头盔和口插入式探测器组合而成，称为头盔口插入式PET。结果表明，与头盔下巴 PET 相比，头盔嘴插入 PET 的灵敏度与半球中心附近的灵敏度相当，并且空间分辨率有所提高。

项目成果

Imaging simulation of a D-shape PET scanner for improved sensitivity and reduced cost in a whole-body imaging

D 形 PET 扫描仪的成像模拟可提高全身成像的灵敏度并降低成本

• 发表时间: 2017
• 作者: Abdella M. Ahmed;Hideaki Tashima;Taiga Yamaya
• 通讯作者: Taiga Yamaya

Simulation study of a D-shape PET scanner for improved sensitivity and reduced cost in whole-body imaging

D 形 PET 扫描仪的模拟研究，以提高全身成像的灵敏度并降低成本

• DOI: 10.1088/1361-6560/aa6853
• 发表时间: 2017
• 期刊: Physics in Medicine & Biology
• 影响因子: 3.5
• 作者: Abdella M Ahmed;Hideaki Tashima and Taiga Yamaya
• 通讯作者: Hideaki Tashima and Taiga Yamaya

Simulation study comparing the helmet-chin PET with a cylindrical PET of the same number of detectors

• DOI: 10.1088/1361-6560/aa685c
• 发表时间: 2017-06-07
• 期刊: PHYSICS IN MEDICINE AND BIOLOGY
• 影响因子: 3.5
• 作者: Ahmed, Abdella M.;Tashima, Hideaki;Yamaya, Taiga
• 通讯作者: Yamaya, Taiga

The “bed-PET”: a proposed geometry for a highly sensitive and affordable whole body PET scanner

“bed-PET”：高灵敏度且经济实惠的全身 PET 扫描仪的拟议几何结构

• 发表时间: 2016
• 作者: Abdella M. Ahmed;Hideaki Tashima;Eiji Yoshida;Taiga Yamaya
• 通讯作者: Taiga Yamaya

Detector Size and Geometry Optimization for the Helmet-Chin PET

头盔下巴 PET 的探测器尺寸和几何优化

• 发表时间: 2016
• 作者: Abdella;M. Ahmed;Hideaki Tashima;Eiji Yoshida;Taiga Yamaya
• 通讯作者: Taiga Yamaya