HETEROSTRUCTURE RADIATION DETECTOR MATERIALS FOR ADVANCED TIME OF FLIGHT POSITRON EMISSION TOMOGRAPHY (TOF-PET) IMAGING

用于高级飞行时间正电子发射断层扫描 (TOF-PET) 成像的异质结构辐射探测器材料

• 批准号: EP/S013652/1
• 负责人: Gregory Bizarri
• 金额: $ 78.76万
• 依托单位: CRANFIELD UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS013652%2F1
• 关键词: HETEROSTRUCTURE; RADIATION; DETECTOR; MATERIALS; ADVANCED

This proposal aims at developing advanced radiation detector materials for Time of Flight Positron Emission Tomography (ToF-PET) imaging by exploiting the novel concept of high performance multi-material radiation sensing heterostructures. These heterostructures will contribute to the development of next generation imaging technologies for diagnostic, monitoring and therapeutic applications, specifically, by substantially improving the capabilities of ToF-PET technology. These heterostructures will enable i) enhanced diagnostic power; ii) reduced risk to patients (dose efficiency); iii) increased procedural flexibility (i.e. planning of radiation dose strategies and reduced examination time); and eventually iv) direct ToF-PET imaging by rendering the currently time-consuming post-acquisition reconstruction stage obsolete. This effort will be supported by multi-disciplinary facilitation of the design, fabrication and characterisation of the heterostructures, in order to develop an advanced detector material solution for use in current and future ToF-PET detector modules. The output and impact of the research will be maximised through functional testing of the proposed heterostructure detector module. The proposal matches the aspirations of the EPSRC's Healthcare Technologies research theme by i) optimising treatment and care through effective diagnosis, patient-specific prediction and evidence-based intervention; ii) supporting the development of technologies to enhance efficacy, minimise costs and reduce risk to patients; and iii) bringing together a multidisciplinary team with expertise in material science, precision engineering and instrumentation, who will be further supported by external advisors, ToF-PET experts and industrial partners for providing guidance and ensuring the transformational impact of the proposed effort.

该提案旨在通过利用高性能多材料辐射传感异质结构的新概念来开发用于飞行时间正电子发射断层扫描（ToF-PET）成像的先进辐射探测器材料。这些异质结构将有助于开发用于诊断、监测和治疗应用的下一代成像技术，特别是通过大幅提高ToF-PET技术的能力。这些异质结构将使i）增强诊断能力; ii）降低患者风险（剂量效率）; iii）增加程序灵活性（即规划辐射剂量策略和减少检查时间）;最终iv）通过使目前耗时的ToF-PET成像变得过时采集后重建阶段。这项工作将得到异质结构设计、制造和表征的多学科促进的支持，以开发用于当前和未来ToF-PET探测器模块的先进探测器材料解决方案。通过对拟议的异质结构探测器模块进行功能测试，将最大限度地提高研究的产出和影响。该提案符合EPSRC的医疗保健技术研究主题的愿望，即：i）通过有效的诊断，患者特异性预测和循证干预来优化治疗和护理; ii）支持技术开发，以提高疗效，最大限度地降低成本并降低患者风险;和iii）汇集一支具有材料科学、精密工程和仪器专业知识的多学科团队，他们将得到外部顾问、ToF-PET专家和行业合作伙伴的进一步支持，以提供指导并确保拟议工作的转型影响。

项目成果

Thermal Spray Coatings for Electromagnetic Wave Absorption and Interference Shielding: A Review and Future Challenges

用于电磁波吸收和干扰屏蔽的热喷涂涂层：回顾和未来挑战

• DOI: 10.1002/adem.202200171
• 发表时间: 2022
• 期刊: Advanced Engineering Materials
• 影响因子: 3.6
• 作者: Faisal N

Suppressing the Use of Critical Raw Materials in Joining of AISI 304 Stainless Steel Using Activated Tungsten Inert Gas Welding

使用活性钨极惰性气体保护焊连接 AISI 304 不锈钢时抑制关键原材料的使用

• DOI: 10.3390/met9111187
• 发表时间: 2019
• 期刊: Metals
• 影响因子: 2.9
• 作者: Balos S

Molecular dynamics simulation of AFM tip-based hot scratching of nanocrystalline GaAs

• DOI: 10.1016/j.mssp.2021.105832
• 发表时间: 2021-04-08
• 期刊: MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
• 影响因子: 4.1
• 作者: Fan，Pengfei;Goel，Saurav;Wang，Yuzhang
• 通讯作者: Wang，Yuzhang

Distribution of shallow NV centers in diamond revealed by photoluminescence spectroscopy and nanomachining

• DOI: 10.1016/j.carbon.2020.04.086
• 发表时间: 2020-04
• 期刊: Carbon
• 影响因子: 10.9
• 作者: M. Fazeli Jadidi;H. Özer;S. Goel;J. Kilpatrick;N. McEvoy;D. McCloskey;J. Donegan;G. Cross

An atomistic investigation on the wear of diamond during atomic force microscope tip-based nanomachining of gallium arsenide

• DOI: 10.1016/j.commatsci.2020.110115
• 发表时间: 2021-02-01
• 期刊: COMPUTATIONAL MATERIALS SCIENCE
• 影响因子: 3.3
• 作者: Fan, Pengfei;Goel, Saurav;Wang, Yuzhang
• 通讯作者: Wang, Yuzhang