Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention

本文对小儿病毒性脑炎/脑病的临床特点及发病机制进行了研究。作为病原体，流感病毒是最常见的病毒，其次是HHV-6和轮状病毒，总死亡率为7.7%。根据HHV-6原发感染引起中枢神经系统损害的发病机制（E.脑组织中未发现病毒生长，显示脑病而非脑炎。对于这种疾病的治疗，TRX在不久的将来可能是一个重要的目标。

We have studied on the clinical features and pathogenesis of acute encephalitis/encephalopathy caused by viruses among children. As an causative agent, Influenza virus was a most common virus, followed by HHV-6 and rotavirus, and overall mortality was 7.7%. In terms of the pathogenesis of CNS damage caused by HHV-6 primary infection (E. subitum), virus growth has not been found in the brain tissue, showing encephalopathy not encephalitis. For treatment of this illness, TRX could be an important target in the near future.