Study on the treatment of highly pathogenic avian influenza H5N1 infections by means of the analysis of pathogenesis of the illness

人感染高致病性H5N1禽流感的发病机制与严重肺炎和伴有细胞因子风暴的流感相关脑病的发病机制非常相似。利用微阵列分析方法，我们分析了2009pdm感染急性期的基因表达。有趣的是，基因表达谱在肺炎患者和有中枢神经系统表现的患者之间是不同的。特别是与ROD相关的基因表达已被高度激活。通过小鼠模型，我们已经证明硫氧还蛋白-1（TRX）可以抑制氧化应激和炎症变化，从而改善流感病毒感染肺炎的预后。综上所述，TRX等抗氧化应激剂可能在伴有H5N1感染的严重肺炎/ARD中发挥重要作用。

The pathogenesis of highly pathogenic avian influenza H5N1 in humans has been closelsimilar to those of severe pneumonia and influenza-associated encephalopathy witcytokine storm. Using microarray assay we have analyzed gene expression in the acute phasof 2009pdm infection. Interestingly, gene expression profiles were different betweepneumonia patients and patients with CNS manifestations. Particularly, gene expressiorelated to ROD has been highly activated. Using mouse model, we have shown that thioredoxin-1(TRX) could suppress the oxidativstress and inflammatory changes resulting better outcome in pneumonia with influenzvirus infections. Taking together, anti-oxidant stress agents such as TRX could play an important rolin the severe pneumonia/ARD with H5N1 infections.