Pathogenesis on Viral Encephalitis/Encephalopathy

病毒性脑炎/脑病的发病机制

• 批准号: 12670745
• 负责人: MORISHIMA Tsuneo
• 金额: $ 2.43万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670745/
• 关键词: acute encephalitis; acute encephalopathy; herpes simplex virus; neonatal herpes; influenza virus; measles virus; SSPE; cytokines; EBウイルス; HHV-6; インフルエンザ; エンテロ71脳炎; インフルエンザ脳炎; インフルエンザ脳症; 単純ヘルペス脳炎; E-セレクチン

Annual Incidence of acute encephalitis/encephalopathy among children is approximately 1,000-2,000 cases. The aim of this study was to investigate epidemiology, clinical features, virological studies, pathogenesis, treatment and prevention on 1. herpes simplex encephalitis, 2. neonatal herpes, 3. influenza associated encephalopathy, 4. SSPE 5. others diseases.1. Herpes simplex encephalitis : We have shown that the relapse of the illness occurred frequently among children and insufficient treatment with antiviral agents was one of the important factors of the relapse.2. Neonatal herpes : In cases with HSV type 2 infection, significantly higher amount of viral DNA was demonstrated in CSF, and CNS involvement occurred more frequently than type 1. Moreover, relapse also occurred frequently in type 2 infection.3. AH3 subtype of influenza virus causes the acute encephalopathy more frequently in young children than the other subtypes of the virus. High concentration of cytokines was found in sera and CSF and damage of vascular endothelial cells was demonstrated.4. In the treatment of SSPE, intraventricular injection of interferon alpha and ribavirin was done under the permission of Ethical Committee of Nagoya Univ., and growth inhibitory effects of the virus was demonstrated.

儿童急性脑炎/脑病的年发病率约为1，000 - 2，000例。本研究的目的是调查流行病学，临床特征，病毒学研究，发病机制，治疗和预防1。单纯疱疹病毒性脑炎，2.新生儿疱疹，3.流感相关脑病，4. SSPE 5.其他疾病1.单纯疱疹病毒性脑炎：我们的研究表明，该病在儿童中经常复发，抗病毒药物治疗不足是复发的重要因素之一.新生儿疱疹：在HSV 2型感染的病例中，CSF中的病毒DNA量显著高于1型，CNS受累的发生率高于1型。此外，2型感染也经常复发. AH 3亚型流感病毒比其他亚型流感病毒更常引起幼儿急性脑病。血清和脑脊液中细胞因子浓度升高，血管内皮细胞受损. SSPE的治疗经名古屋大学伦理委员会批准，并证明了病毒的生长抑制作用。

项目成果

Morishima T, et al.: "Natural killer cell prollferation and circulaiing cytokines in patients with bilat eral basal ganglia calcification."European Journal of Neurology. 9. 521-525 (2002)

Morishima T 等人：“双侧基底神经节钙化患者的自然杀伤细胞增殖和循环细胞因子。”欧洲神经病学杂志。

Kasai T.,Togashi M.and Morishima T.: "Encephalopathy associated with influenza epidemics."Lancet. 355. 1558-9 (2000)

Kasai T.、Togashi M. 和 Morishima T.：“与流感流行相关的脑病”。《柳叶刀》。

Kawada J, et al.: "Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7"Ped Infect Dis J. (in press).

Kawada J 等人：“流感相关脑病与人类疱疹病毒 6 型或人类疱疹病毒 7 型之间不存在关联”Ped Infect Dis J.（出版中）。

安藤嘉浩, 小出照子, 栄 賢司, 木村 宏, 森島恒雄: "中枢神経合併症を伴うエンテロウイルス71感染"小児科臨床. (印刷中). (2002)

Yoshihiro Ando、Teruko Koide、Kenji Sakae、Hiroshi Kimura、Tsuneo Morishima：“肠道病毒 71 感染与中枢神经系统并发症”儿科临床（2002 年）。

Ito Y.,Kimura H.,Yabuta Y.,Ando Y.,Murakami T.,Shiomi M.and Morishima T.: "Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir."Clin.Infect.Dis.. 30(1). 185-7 (2000)

Ito Y.、Kimura H.、Yabuta Y.、Ando Y.、Murakami T.、Shiomi M. 和 Morishima T.：“阿昔洛韦成功治疗后单纯疱疹脑炎恶化。”Clin.Infect.Dis.. 30（