Development of novel radiopharmaceuticals for diagnosis of cerebral neurodegeneration and functional recovery after intrastriatal grafts/gene therapy

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As a result of analyzing by PET tracers relevant to function analysis of cerebral dopaminergic neuron using the transplant group which was transplanted the rat intrastriatal grafts of fetal ventral mesencephalon of a Parkinson's disease model rat aiming at the diagnostic application to the regeneration effect of medicine, the individual specificity in a transplant group was large, but the significant correlation was acquired between the functional recovery by the degree of methamphetamine-induced rotation test and immunity dyeing analysis. Furthermore, functional change of cerebral dopaminergic neuron in a psychiatry drug administration model rat was also evaluated, the gene expression level of the functional molecule relevant to the nervous function in the pathological part after a transplant or drug administration was analyzed comprehensively, and comparison examination was carried out with functional change of cerebral dopaminergic neuron.