Medical innovation for diabetes care by introducing non-invasive diagnostic system against small tissues

本研究成功建立了可在15分钟内准确测量多个小组织呼吸活动的临床应用新系统。通过应用该系统，我们发现葡萄糖刺激离体胰岛的呼吸活动与胰岛移植后的移植物功能显著相关，提示该系统可作为离体胰岛效价检测的可靠方法。此外，还证明了本研究建立的体系可用于开发新的胰岛分离酶和新的胰岛分离培养装置。

In the present study, clinically applicable new system in which the respiratory activity of multiple small tissues can be measured accurately in 15 minutes was successfully established. By applying this novel system, it was demonstrated that the glucose stimulated respiratory activity of isolated pancreatic islets was significantly correlated with the graft function after islet transplantation, suggesting that this could be used as a reliable potency test for isolated islets. Furthermore, it was also proved that established system in the present study could be useful for developing a new enzyme of islet isolation and a new culture device of isolated islets.