Medical innovation for diabetes care by introducing non-invasive diagnostic system against small tissues

通过引入针对小组织的非侵入性诊断系统，实现糖尿病护理的医疗创新

• 批准号: 20249057
• 负责人: SATOMI Susumu
• 金额: $ 30.95万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20249057/
• 关键词: 糖尿病; 細胞; 組織; 膵島; 移植; 細胞・組織

In the present study, clinically applicable new system in which the respiratory activity of multiple small tissues can be measured accurately in 15 minutes was successfully established. By applying this novel system, it was demonstrated that the glucose stimulated respiratory activity of isolated pancreatic islets was significantly correlated with the graft function after islet transplantation, suggesting that this could be used as a reliable potency test for isolated islets. Furthermore, it was also proved that established system in the present study could be useful for developing a new enzyme of islet isolation and a new culture device of isolated islets.

本研究成功建立了可在15分钟内准确测量多个小组织呼吸活动的临床应用新系统。通过应用该系统，我们发现葡萄糖刺激离体胰岛的呼吸活动与胰岛移植后的移植物功能显著相关，提示该系统可作为离体胰岛效价检测的可靠方法。此外，还证明了本研究建立的体系可用于开发新的胰岛分离酶和新的胰岛分离培养装置。

项目成果

Monitoring transplanted islets by high-frequency ultrasound

• DOI: 10.4161/isl.3.5.17058
• 发表时间: 2011-09-01
• 期刊: ISLETS
• 影响因子: 2.2
• 作者: Sakata, Naoaki;Kodama, Tetsuya;Unno, Michiaki
• 通讯作者: Unno, Michiaki

グラフト保護プロトコールの導入により良好な結果を得た急性腹膜炎下における自家膵島移植症例の報告

急性腹膜炎自体胰岛移植一例，引入移植物保护方案取得良好效果。

• 发表时间: 2011
• 作者: Ogino T;Ozaki M;Hosako M;Omori M;Okada S;Matsukawa A;後藤昌史
• 通讯作者: 後藤昌史

膵島移植の現状と課題

胰岛移植的现状及问题

• 发表时间: 2011
• 期刊: 総合臨床
• 作者: Hattori E;Toyota T;Ishitsuka Y;Iwayama Y;Yamada K;Ujike H;Morita Y;Kodama M;Nakata K;Minabe Y;Nakamura K;Iwata Y;Takei N;Mori N;Naitoh H;Yamanouchi Y;Iwata N;Ozaki N;Kato T;Nishikawa T;Kashiwa A;Suzuki M;Shioe K;Shinohara M;Hirano ;森島恒雄;後藤昌史
• 通讯作者: 後藤昌史

膵島分離用酵素剤の活性評価システムの構築

胰岛分离酶制剂活性评价体系的构建

• 发表时间: 2010
• 作者: 芳賀早苗;森田直樹;小澤岳昌;レミントンジェームズ;尾崎倫孝;後藤昌史
• 通讯作者: 後藤昌史

有用な膵島評価法である呼吸活性計測法の実際

呼吸活动测量的实践，评估胰岛的有用方法

• 发表时间: 2008
• 作者: Kadono Y;Yasunaga H;Horiguchi H;Hashimoto H;Matsuda M;Tanaka S;Nakamura S.;後藤昌史
• 通讯作者: 後藤昌史