High-throughput development of disease model mice by using next-generation technologies.

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We have established ultra-throughput point mutation discovery system from the RIKEN ENU mutant mouse library. Based on this unique system, it is now possible to detect base substitutions with more than 1000-fold efficiency than those by conventional methods. The discovered mutations are openly available as live mutant mice to the research community. Furthermore, any epistatic interactions modeling complex traits/disease have also become detectable from the RIKNE ENU mutant mouse library.