Molecular immunopathology of human cancer stem cell

人类癌症干细胞的分子免疫病理学

• 批准号: 21249025
• 负责人: SATO Noriyuki
• 金额: $ 29.45万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249025/
• 关键词: 分子病理; 癌幹細胞; 腫瘍抗原; CTL; 癌免疫; 分子標的; SP法; CSC/CIC; CSC; CIC

This study was aimed to analyze molecular pathological nature of human cancer stem cell(CSC)/cancer-initiating cell(CIC). Particularly we studied molecules expressed specifically in CSC/CIC and their immunological characteristics. Consequently we successfully identified such interesting antigens. These antigens have molecular features of cancer-testis antigens, and could work as potential immunogenic molecule in human cancers.

本研究旨在分析人肿瘤干细胞（CSC）/肿瘤起始细胞（CIC）的分子病理学本质。特别是研究了CSC/CIC中特异性表达的分子及其免疫学特性。因此，我们成功地鉴定了这些有趣的抗原。这些抗原具有肿瘤-睾丸抗原的分子特征，有可能成为潜在的免疫原性分子。

项目成果

The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma

• DOI: 10.1016/j.yexmp.2010.10.001
• 发表时间: 2011-02-01
• 期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY
• 影响因子: 3.6
• 作者: Inoda, Satoko;Morita, Rena;Sato, Noriyuki
• 通讯作者: Sato, Noriyuki

Spatiotemporal Regulation of Heat Shock Protein 90-Chaperoned Self-DNA and CpG-Oligodeoxynucleotide for Type I IFN Induction via Targeting to Static Early Endosome

• DOI: 10.4049/jimmunol.1000490
• 发表时间: 2010-06-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Okuya, Koichi;Tamura, Yasuaki;Sato, Noriyuki
• 通讯作者: Sato, Noriyuki

Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma.

识别自体口腔鳞状细胞癌的细胞毒性 T 淋巴细胞的克隆多样性。

• 发表时间: 2009
• 期刊: Hum Immunol. 70
• 作者: Kobayashi;J.;Sato;N.;他9名、11番目
• 通讯作者: 他9名、11番目

Pathology-based development of human cancer immunotherapy

基于病理学的人类癌症免疫疗法的开发

• 发表时间: 2009
• 作者: Sato;N.
• 通讯作者: N.

サバイビン由来のHLA-A 24結合性癌抗原ペプチド

源自生存素的 HLA-A 24 结合癌抗原肽

• 发表时间: 2010