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Measles pathogenesis as studied using animal models

Measles pathogenesis as studied using animal models
使用动物模型研究麻疹发病机制
批准号:
21249032
负责人:
YANAGI Yusuke
金额:
$29.62万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012

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中文摘要
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英文摘要
SLAM knockin mice well reproduced immunological abnormalities observed in human measles. However, measles virus only grew in type I interferon receptor knockout mice, since it could not effectively counteract type I interferons in mouse cells. To overcome this problem, transgenic mice were established in which type I interferons are suppressed in measles virus-infected cells. Furthermore, it was demonstrated using 10-day-old suckling hamsters that enhanced fusion activity of the measles virus fusionprotein plays an important role in measles virus spread in neuronal cells that lack efficient receptors.
期刊论文(27)
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会议论文
麻疹ウイルス-膜融合機構と新しい動物モデルの開発-
麻疹病毒-膜融合机制及新动物模型的开发-
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Morohashi K, et al., 柳 雄介]
通讯作者: 柳 雄介
Novel mutations in the measles virus fusion protein that enhance its fusion activity
麻疹病毒融合蛋白的新突变增强了其融合活性
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Watanabe S, Shirogane Y, Ikegame S, Koga R, Nakashima M, Yanagi Y]
通讯作者: Yanagi Y
細胞融合能を促進させる、麻疹ウイルスF蛋白質の新規アミノ酸変異の同定
麻疹病毒F蛋白中促进细胞融合能力的新氨基酸突变的鉴定
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [渡辺俊平, 白銀勇太, 池亀聡, 古賀律子, 柳雄介]
通讯作者: 柳雄介
マウス神経細胞の麻疹ウイルス感染
麻疹病毒感染小鼠神经元
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [古賀 律子, 池亀聡, 大野真治, 渡辺俊平, 柳 雄介]
通讯作者: 柳 雄介
17
    Mechanism of measles virus spread in the brain
    Development of new therapy for congenital metabolic disorders using functional three-dimensional liver structures constructed by stem cells from human exfoliated deciduous teeth
    • 批准号:
      24592696
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2012
    • 负责人:
      YANAGI Yusuke
    • 依托单位:
    Analysis of measles pathogenesis using the mouse model expressing measles virus receptor SLAM and recombinant viruses
    • 批准号:
      17209016
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $32.45万
    • 财政年份:
      2005
    • 负责人:
      YANAGI Yusuke
    • 依托单位:
    INTERACTION BETWEEN MEASLES VIRUS AND INNATE IMMUNITY
    • 批准号:
      15390151
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.09万
    • 财政年份:
      2003
    • 负责人:
      YANAGI Yusuke
    • 依托单位:
    海外基金