Measles pathogenesis as studied using animal models
Measles pathogenesis as studied using animal models
批准号:
21249032
负责人:
YANAGI Yusuke
金额:
$29.62万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
SLAM knockin mice well reproduced immunological abnormalities observed in human measles. However, measles virus only grew in type I interferon receptor knockout mice, since it could not effectively counteract type I interferons in mouse cells. To overcome this problem, transgenic mice were established in which type I interferons are suppressed in measles virus-infected cells. Furthermore, it was demonstrated using 10-day-old suckling hamsters that enhanced fusion activity of the measles virus fusionprotein plays an important role in measles virus spread in neuronal cells that lack efficient receptors.
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麻疹ウイルス-膜融合機構と新しい動物モデルの開発-
麻疹病毒-膜融合机制及新动物模型的开发-
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Morohashi K, et al., 柳 雄介]
通讯作者:
柳 雄介
Novel mutations in the measles virus fusion protein that enhance its fusion activity
麻疹病毒融合蛋白的新突变增强了其融合活性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Watanabe S, Shirogane Y, Ikegame S, Koga R, Nakashima M, Yanagi Y]
通讯作者:
Yanagi Y
細胞融合能を促進させる、麻疹ウイルスF蛋白質の新規アミノ酸変異の同定
麻疹病毒F蛋白中促进细胞融合能力的新氨基酸突变的鉴定
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[渡辺俊平, 白銀勇太, 池亀聡, 古賀律子, 柳雄介]
通讯作者:
柳雄介
マウス神経細胞の麻疹ウイルス感染
麻疹病毒感染小鼠神经元
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[古賀 律子, 池亀聡, 大野真治, 渡辺俊平, 柳 雄介]
通讯作者:
柳 雄介
センダイウイルスCタンパク質は麻疹ウイルスのマウス培養細胞での増殖を促進する
仙台病毒C蛋白促进培养小鼠细胞中麻疹病毒的增殖
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[岩崎正治, 池亀聡, 白銀勇太, 柳雄介]
通讯作者:
柳雄介
共 17 条
Mechanism of measles virus spread in the brain
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批准号:20H00507
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.7万
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财政年份:2020
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负责人:YANAGI Yusuke
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依托单位:
Development of new therapy for congenital metabolic disorders using functional three-dimensional liver structures constructed by stem cells from human exfoliated deciduous teeth
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批准号:24592696
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2012
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负责人:YANAGI Yusuke
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依托单位:
Analysis of measles pathogenesis using the mouse model expressing measles virus receptor SLAM and recombinant viruses
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批准号:17209016
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.45万
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财政年份:2005
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负责人:YANAGI Yusuke
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依托单位:
INTERACTION BETWEEN MEASLES VIRUS AND INNATE IMMUNITY
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批准号:15390151
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2003
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负责人:YANAGI Yusuke
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依托单位:
Measles virus receptors and the pathogenesis of measles
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批准号:13226089
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$41.34万
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财政年份:2001
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负责人:YANAGI Yusuke
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依托单位:
Tropism and pathogenesis of measles virus
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批准号:13470064
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.5万
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财政年份:2001
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负责人:YANAGI Yusuke
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依托单位:
Identification of the cellular receptor for measles virus
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批准号:10470079
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$7.04万
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财政年份:1998
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负责人:YANAGI Yusuke
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依托单位:
Cellular receptor for measles virtus
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批准号:08457097
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.22万
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财政年份:1996
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负责人:YANAGI Yusuke
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依托单位:
Molecular mechanism of measles virus-induced immunosuppression
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批准号:06670322
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:YANAGI Yusuke
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依托单位:
T cell antigen receptor and chain genes and MHC restriction
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批准号:61570235
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1986
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负责人:YANAGI Yusuke
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依托单位:
海外基金