in situ Tissue Engineering and its application for air? way reconstruction

在这个项目中，我们挑战使用新的胶原蛋白基质来改善人工气管的生物相容性。还尝试用体干细胞来增强上皮形成，以尝试未来的临床应用。建立了犬iPS细胞，这是世界上第一个报告。MSC还是自体骨？骨髓抽吸物促进管腔表面的上皮形成，而空气呢？直径较小的支气管，如左主支气管可以安全重建。作为一个突出的旋转？在本项目中，建立了最快的方法，使用4种因子的组合（Oct 3/4，Sox 2，Klf 4，n？Myc）和几种化学物质。

In this project, we challenged the improvement of biocompartibility of the artificial trachea using a new collagen matrix. Enhancement of epithelisation was also tried with somatic stem cells in an attempt to future clinical application. Establishment of canine iPS cells, that was the first report of the world, was achieved. MSC or autologous bone? marrow aspirate promotes the epithelisation of lumina' surface, and that the air? way of smaller diameter, such as the left main bronchus can be safely reconstructed. As a prominent spin? off of this project, the fastest method of were established making human iPS cells using a combination of 4 factors(Oct 3/4, Sox 2, Klf 4, n? Myc) and several chemical substances.