Development of canine iPS cells and new in situ Tissue Engineering for airway reconstruction

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We challenged to make an iPS cell from a somatic cell of beagle dog using 4 Yamanaka factors(Oct3, Sox2, Klf4, c-Myc) that were induced by retrovirus, however constant silencing has not yet been recognized.With regard to the regeneration scaffold for airway, new tracheal prosthesis was manufactured with bioabsorbable vicryl mesh reinforced with polypropylene stent with a diameter of 1 mm. In animal experiment in canine, it was determined that conquer of dehiscence between mesh and stent is of importance after the implantation.