Novel tracheal reconstruction using iPS cells of Beagle dogs.

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We challenged to establish new iPS cell line from adult Beagle dogs, but it was much difficult than we had expected before the beginning of this experiment, to reset the mature cells of Beagle dogs. Hence we could not establish the cell line within the study period. However it was revealed the potential of ADS cells or bone mallow cell to the cell source of in situ Tissue Engineering instead of iPS cells. This method will contribute the reconstruction of airway as a new surgical approach. The reason may be due to the difference of the aging of the cell source, namely the cell from adult Beagle dog may have an unknown mechanism which works against the reprograming.