Neural correlates of visual ambiguity and meta-perceptual confidence rating

视觉模糊性和元知觉置信度的神经相关性

• 批准号: 508592246
• 负责人: Privatdozent Dr. Jürgen Kornmeier
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/508592246?language=en
• 关键词: Neural; correlates; visual; ambiguity; meta

The information available to our senses is incomplete and ambiguous. Our perceptual system normally integrates this the bottom-up sensory information with top-down perceptual memories in order to resolve this ambiguity and to construct stable and reliable percepts. During observation of an ambiguous figure our perception becomes unstable and alternates between two equally probable but mutual exclusive interpretations. We recently found two ERP components (P200 and P400) with small vs. large amplitudes evoked by ambiguous figures vs. disambiguated figure variants (ERP Ambiguity Effects). These unusually strong effects generalize across very different visual categories and complexity levels (motion, semantics, emotional face expressions and letters/numbers). A recent study with Necker cube stimuli revealed perfect confirmation of a predictive coding model about perceptual processing. The model indicates that the P200 correlates with top-down contributions to the perceptual process. The P400 seems to reflect the integration of bottom-up and top-down elements and thus the reliability of the perceptual outcome. These findings and the introduced model are the starting point of this grant proposal consisting of three projects:Project A: Testing for generalizability across visual categories and complexity levelsSo far, the relation between the ERP Ambiguity Effects and the predictive coding model has only been shown for Necker cube stimuli. We plan to test whether these model-conform findings generalize across other stimulus categories and complexity levels mentioned above.Project B: Test for ERP Ambiguity Effects alterations in SSD PatientsPatients with schizophrenia spectrum disorder (SSD) show deficits in integrating bottom-up sensory with top-down information. We plan to test whether this integration deficit is reflected in a deviated pattern of ERP Ambiguity Effects. Project C: Testing for generalizability of the ERP Ambiguity Effects concerning neural sourcesThe spatial locations of the ERP Ambiguity Effects are so far based on EEG voltage maps. The aims of this subproject are, using concurrent EEG/fMRI recordings: (1) To specify whether similar ERP scalp distributions across different stimulus categories and complexity levels are based on the same underlying neural sources, as predicted by the model. (2) To identify brain areas underlying perceptual disambiguation processes and respective differences between SSD patients and controls. The results of this project at the interface between neurobiology, psychology of perception and psychiatry may advance the understanding of the neural and functional features of the ERP Ambiguity Effects and predictive coding approaches to perception. Given the large sizes of the ERP Ambiguity Effects, the results from the current project may have a good prospect for future clinical applications.

我们的感官所能获得的信息是不完整和模糊的。我们的感知系统通常将自下而上的感觉信息与自上而下的感知记忆整合在一起，以解决这种模糊性并构建稳定可靠的感知。在观察一个模糊的图形时，我们的知觉变得不稳定，并在两种可能性相等但相互排斥的解释之间交替。我们最近发现了两个ERP成分（P200和P400）与小与大的幅度引起的模糊的数字与消除歧义的数字变体（ERP模糊效应）。这些异常强烈的效果概括了非常不同的视觉类别和复杂程度（运动，语义，情感面部表情和字母/数字）。最近的一项研究与内克尔立方体刺激揭示了完美的确认预测编码模型的知觉加工。该模型表明，P200与自上而下的知觉过程的贡献。P400似乎反映了自下而上和自上而下元素的整合，从而反映了感知结果的可靠性。这些发现和引入的模型是本基金申请的出发点，包括三个项目：项目A：测试跨视觉类别和复杂性水平的概括性到目前为止，ERP歧义效应和预测编码模型之间的关系只显示了内克尔立方体刺激。我们计划测试这些符合模型的发现是否适用于其他刺激类别和上述复杂性levels.Project B：Test for ERP Ambiguity Effects alterations in SSD PatientsPatients精神分裂症谱系障碍（SSD）患者在整合自下而上的感觉和自上而下的信息方面表现出缺陷。我们计划测试这种整合赤字是否反映在ERP模糊效应的偏离模式。项目C：关于神经源的ERP模糊效应的普遍性检验ERP模糊效应的空间定位迄今为止是基于EEG电压图。这个子项目的目的是，使用并发的EEG/fMRI记录：（1）确定不同刺激类别和复杂程度的相似ERP头皮分布是否基于相同的潜在神经源，如模型所预测的。(2)确定SSD患者和对照组感知消歧过程的脑区及其差异。该项目在神经生物学，感知心理学和精神病学之间的界面上的结果可能会促进对ERP模糊效应和感知预测编码方法的神经和功能特征的理解。鉴于ERP模糊效应的大尺寸，本项目的结果可能具有良好的前景，为未来的临床应用。