Design and Control of Advanced Molecular Assembly Systems

先进分子组装系统的设计和控制

• 批准号: 08CE2005
• 负责人: SHINKAI Seiji
• 金额: $ 1026.27万
• 依托单位: Kyushu-University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for COE Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08CE2005/
• 关键词: high spin molecule; molecular magnetic complex; organic zeolite; nitrogen-containing cage molecule; molecular orientation; synthetic bilayer unit; molecular recogition unit; multi-nuclear metal complex

In this project, we first established strategies for assembling and organizing molecules on the basis of two guiding principles that, when properly designed, molecules can attract or repel each other selectively, and that dimensionality of the structures is most instrumental in controlling the properties and functions of molecular assemblies. We then designed molecules that have the functional groups for exhibiting weak intermolecular interactions such as coordination bonds, hydrogen bonds, hydrophobic interactions, dispersion force, exchange interaction, etc. The varieties, numbers, locations and vectors of such groups will tailor the size and shape of the resulting molecular assemblies. After the synthesis of the designed component molecules, the assemblage and organization of them have been performed by : 1. Self-assembly, 2. crystallographic technology, 3. monolayer/bilayer methods, 4. molecular manipulation by scanning probe microscopy. These methods will be applied not only for s … More ingle components but also for two or more components.Since mechanical, optical, electronic, magnetic and chemical interactions are expected to be directional and anisotropic in these organized molecular assemblies of mesoscopic scale, the following molecular functions and functional molecular materials which have never been attained by assemblies of naive molecules will be produced. One-dimensional materials : Double-helix information storage mimicking DNA, molecular sensing, highly ordered metal-ion array catalysts, Two-dimensional materials : Creation of morphologies found in living organism, interfaces enabling chiral recognition, two-dimensional metal complexes Three-dimensional materials : Two-dimensional reaction environments by multiplication of artificial molecular bilayers, organic zeolites, molecular optomagnetic recording devices, transparent magnets.We believe that research achievements obtained through this Project will become a milestone linking the 20th century to the 21st century and open a door toward the new era of science. Less

在这个项目中，我们首先在两个指导原则的基础上建立了组装和组织分子的策略，这两个指导原则是：如果设计得当，分子可以选择性地相互吸引或排斥，并且结构的维度对控制分子组装的性质和功能最有帮助。然后，我们设计了具有表现出弱分子间相互作用的官能团的分子，如配位键、氢键、疏水相互作用、分散力、交换作用等。这些基团的种类、数量、位置和载体将定制得到的分子组装的大小和形状。在设计的组成分子合成后，它们的组装和组织通过：1.自组装，2.结晶学技术，3.单/双分子层方法，4.扫描探针显微镜的分子操纵。这些方法不仅适用于S…由于在这些介观尺度的有序分子组装中，机械、光学、电子、磁和化学相互作用预计是定向的和各向异性的，因此将产生以下分子功能和功能分子材料，这些功能和功能分子材料是通过天然分子组装从未获得的。一维材料：模拟DNA的双螺旋信息存储、分子传感、高度有序的金属离子阵列催化剂、二维材料：在生物体中发现的形态的创造、手性识别的界面、二维金属络合物三维材料：人工分子双层、有机沸石、分子光磁记录装置、透明磁的倍增的二维反应环境。我们相信，通过这项计划所取得的研究成果将成为连接20世纪和21世纪的里程碑，并打开通往新科学时代的大门。较少

项目成果

O.Hayashida, C.Shimizu, T.Fujimoto, Y.Aoyama: "Surface Plasmon Resonance Study on the Interaction of Immobilized Macrocyclic Suger Clusters with Lectins and Water-Soluble Polymers" Chem.Lett.13-14 (1998)

O.Hayashida、C.Shimizu、T.Fujimoto、Y.Aoyama：“固定化大环糖簇与凝集素和水溶性聚合物相互作用的表面等离子共振研究”Chem.Lett.13-14 (1998)

K.Oshima, Y.Aoyama: "Regiospecific Glycosidation of Unprotected Sugars via Arylboronic Activation" J.Am.Chem.Soc.121(in press). (1999)

K.Oshima、Y.Aoyama：“通过芳基硼酸活化未受保护的糖的区域特异性糖苷化”J.Am.Chem.Soc.121（印刷中）。

T.Sawaki, Y.Aoayama: "Immobilization of a Soluble Metal Complex in an Organic Network. Remarkable Catalytic Performance of a Porous Dialkoxyzirconium Polyphenoxide As a Functional Organic Zeolite Analogue" J.Am.Chem.Soc.121(in press). (1999)

T.Sawaki、Y.Aoayama：“可溶性金属络合物在有机网络中的固定化。多孔二烷氧基多苯氧基锆作为功能性有机沸石类似物的显着催化性能”J.Am.Chem.Soc.121（印刷中）。

N.Kamiya, M.Inoue, M.Goto, N.Nakamura, Y.Naruta: "Catalytic and Structural Properties of Surfactant-Horseradish Peroxidase Complex in Organic Media" Biotechnology Progress. (発表予定). (1999)

N.Kamiya、M.Inoue、M.Goto、N.Nakamura、Y.Naruta：“有机介质中表面活性剂-辣根过氧化物酶复合物的催化和结构特性”生物技术进展（即将发表）。

Y.Tachi, S.Nakayama, F.Tani, Y.Naruta: "(S)-3,3'-Diformyl-2,2'-di(methoxymethoxy)-1,1'-binaphthyl" Acta Cryst.A. 発表予定 (1999)

Y.Tachi、S.Nakayama、F.Tani、Y.Naruta：“(S)-3,3-二甲酰基-2,2-二(甲氧基甲氧基)-1,1-联萘”Acta Cryst.A。公告时间表（1999）