Construction of non-linear chemical information transaction system using allosteric interaction

利用变构相互作用构建非线性化学信息交易系统

• 批准号: 11450349
• 负责人: SHINKAI Seiji
• 金额: $ 6.98万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11450349/
• 关键词: Allosterism; Supramolecular Chemistry; Non-Linear; Molecular information; Molecular Recognition; アリステリズム; 情報伝達; ポルフィリン; ダブルデッカー型錯体; アロステリズム; シグナル増幅; 糖質; ボロン酸

The positive homotropic allosterism appears in important information transduction processes where chemical and physical signals are efficiently amplified. The phenomena are ubiquitously seen in nature but the general methodology to design such allosteric systems is not yet established in an artificial system. This article reviews such artificial receptors that can bind guest ions and molecules in a positive allosteric manner and discusses what kinds of factors are indispensable as scaffolds to design this novel class of allosteric systems and what are the common factors to realize the cooperativity. It has been shown that the scaffolds are mostly dynamic and are skillfully combined with the molecular recognition systems so that the subsequent guest binding can occur more favorably than the first guest binding. In addition, it has been suggested that the positive homotropic allosterism can be utilized as a new strategy to attain high guest selectivity and guest affinity which cannot be attained by conventional 1 : 1-type guest binding.

正性各向同性变构作用出现在化学和物理信号被有效放大的重要信息转导过程中。这种现象在自然界中随处可见，但设计这种变构系统的一般方法尚未在人工系统中建立。本文综述了能够以正变构方式与客体离子和分子结合的人工受体，并讨论了设计这类新型变构体系所必需的支架因子以及实现协同作用的共同因子。研究表明，这些支架大多是动态的，并且与分子识别系统巧妙地结合在一起，因此后续的客体结合可以比第一个客体结合发生得更有利。此外，还提出了正的各向同性变构作用可以作为一种新的策略来获得高的客体选择性和客体亲和力，这是传统的1：1型客体结合所不能达到的。

项目成果

M.Ikeda, S.Shinkai, A.Osuka: "Meso-meso-linked Porphyrin Dimer as a novel Scaffold for the Selective Binding of Oliaosaccharides"Chem. Commun.. 1047-1047 (2000)

M.Ikeda、S.Shinkai、A.Osuka：“内消旋-内消旋连接的卟啉二聚体作为选择性结合寡糖的新型支架”Chem。

Y.Kubo, M.Ikeda, A.Sugasaki, M.Takeuchi, S.Shinkai: "Porphyrin Tetramer for Positive Homotropic Allosteric Recognition System : Efficient Binding Information Transduction through Butadiynyl Axis Rotation"Tetrahedron Lett.. 42. 7435-7435 (2001)

Y.Kubo、M.Ikeda、A.Sugasaki、M.Takeuchi、S.Shinkai：“用于正同向变构识别系统的卟啉四聚体：通过丁二炔基轴旋转进行有效的结合信息转导”Tetrahedron Lett.. 42. 7435-7435 (2001)

M.Takeuchi, M.Ikeda, A.Sugasaki, S.Shinkai: "Molecular Design of Artificial Molecular and Ion Recognition System with Allosteric Guest Responses"Acc.Chem.Res.. 34. 865 (2001)

M.Takeuchi、M.Ikeda、A.Sugasaki、S.Shinkai：“具有变构客体响应的人工分子和离子识别系统的分子设计”Acc.Chem.Res.. 34. 865 (2001)

木村 太郎: "Super-structures Can Be Constructed in Organogels from Combination of a Co-rnic-acid appended Bolaamphiphile with Chiral Diols"Tetrahedron Lett.. 40・36. 6631-6634 (1999)

木村太郎：“通过添加玉米酸的 Bolaamphiphile 与手性二醇的组合可以在有机凝胶中构建超结构”Tetrahedron Lett.. 40・36 (1999)。

M.Yamamoto, A.Sugasaki, M.Ikeda, M.Takeuchi, K.Frimat, T.D.James, S.Shinkai: "Efficient Anion Binding to Cerium(IV) Bis(porphyrinate) Double Decker Utilizing Positive Homotropic Allosterism"Chem. Lett.. 520-520 (2001)

M.Yamamoto、A.Sugasaki、M.Ikeda、M.Takeuchi、K.Frimat、T.D.James、S.Shinkai：“利用正同向变构作用与铈 (IV) 双（卟啉）双层结构进行有效阴离子结合”Chem。