Diversity of energy transducing mechanism by organella from the parasites such as Plasmodium

疟原虫等寄生虫的细胞器能量转换机制的多样性

• 批准号: 18GS0314
• 负责人: KITA Kiyoshi
• 金额: $ 336.88万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Creative Scientific Research
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18GS0314/
• 关键词: オルガネラ; 寄生虫; 感染症; エネルギー代謝; 細胞・組織; 進化; 特殊環境; 微生物

Eukaryotic cells possess organella, which are essential for the maintenance of their biological function. By the extensive studies, many new findings on the origin, reaction mechanism and interaction of energy transducing mitochondria and plastid, which are indispensable for the survival of the cells, have been reported. Recent study revealed the unique mitochondria of parasites, which adapt to the anaerobic environment in the host as well as the parasites without mitochondria. However, information on the process of their establishment, details of their physiological functions, interaction between the organella is limited.The aim of this research project is to answer these questions and establish a base of our understanding the diversity of energy transduction in the novel organella, dynamic interaction between the organella and their evolution. In this study, by focusing on parasitic protozoas such as malaria parasite, we have found novel properties of parasite organella, which bring a new insight organella biology.

真核细胞具有维持其生物学功能所必需的细胞器。通过大量的研究，对细胞生存所必需的能量传递线粒体和质体的起源、反应机制和相互作用等方面有了许多新的发现。近年来的研究发现，寄生虫具有独特的线粒体，能适应宿主体内的厌氧环境，而无线粒体的寄生虫也能适应。然而，关于它们的建立过程、生理功能、细胞器之间的相互作用等方面的信息还很有限，本研究旨在回答这些问题，并为我们理解新型细胞器中能量传递的多样性、细胞器之间的动态相互作用及其进化奠定基础。本研究以疟原虫等寄生性原虫为研究对象，发现了寄生性原虫细胞器的新特性，为细胞器生物学的研究提供了新的视角。

项目成果

Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase

• DOI: 10.1107/s1744309110000369
• 发表时间: 2010-03-01
• 期刊: ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
• 影响因子: 0.9
• 作者: Balogun, Emmanuel Oluwadare;Inaoka, Daniel Ken;Kita, Kiyoshi
• 通讯作者: Kita, Kiyoshi

A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinua

一个神秘的藻类群被揭开：牡蛎寄生虫 Perkinsus marinua 中的质体生物合成途径

• 发表时间: 2008
• 期刊: Mol. Biol. Evolution 25
• 作者: Matsuzaki;M.;et al.
• 通讯作者: et al.

Parasitology in Japan : Advances in drug discovery and biochemical studies.

日本寄生虫学：药物发现和生化研究的进展。

• 发表时间: 2007
• 期刊: Trends in Parasitol. (印刷中)
• 作者: Kajiro M;Hirota R;Nakajima Y;Kawanowa K;So-ma K;Ito I;Yamaguchi Y;Ohie S;Kobayashi Y;Seino Y;Kawano M;Kawabe YI;Takei H;Hayashi S;Kurosumi M;Murayama A;Kimura K;Yanagisawa J.;柴田和誠;有賀 健;北 潔 et al.
• 通讯作者: 北 潔 et al.

寄生虫ミトコンドリアの多様性:薬剤標的として

寄生虫线粒体的多样性：作为药物靶点

• 发表时间: 2011
• 作者: S. Takamatsu;T. Ishikawa;S. Koshihara;N. Ishikawa;Tsukaya H.;田中秀治;北潔
• 通讯作者: 北潔

寄生性渦鞭毛藻類Perkinsusのミトコンドリアにおけるribosomal frameshiftを伴う遺伝子発現系

寄生甲藻 Perkinsus 线粒体中具有核糖体移码的基因表达系统

• 发表时间: 2009
• 作者: 増田功;松崎素道;北潔
• 通讯作者: 北潔