Mechanism of host chromosome binding of latently infected Epstein-Barr virus episomes

潜伏感染的Epstein-Barr病毒(EBV)基因组通过病毒编码的EBNA1(Epstein-Barr病毒核抗原1)蛋白附着在宿主染色体上，从而稳定地维持基因组。我们检测了EBNA1的主要结合伙伴细胞p32(TAP，gC1q-R)蛋白是否在EBNA1的染色体结合中发挥了作用。抑制EBV感染细胞中p32的表达并不影响EBNA1的染色体定位。

Latently-infected Epstein-Barr virus(EBV) genomes are stably maintained by attaching to host chromosomes via virally-encoded EBNA1(Epstein-Barr virus Nuclear Antigen 1) protein. We examined whether cellular p32(TAP, gC1q-R) protein, a major binding partner of EBNA1, plays any role in the chromosome binding of EBNA1.Suppression of p32 expression in EBV infected cells did not affect the chromosomal localization of EBNA1.The result argues against the possibility that p32 protein has any role in the chromosome binding of EBNA1.