Mechanism of host chromosome binding of latently infected Epstein-Barr virus episomes

潜伏感染的eb病毒（EBV）基因组通过病毒编码的EBNA1（Epstein-Barr virus Nuclear Antigen 1）蛋白附着在宿主染色体上，从而得到稳定的维持。我们研究了细胞p32（TAP, gC1q-R）蛋白，EBNA1的主要结合伙伴，是否在EBNA1的染色体结合中发挥任何作用。抑制EBV感染细胞中p32的表达不影响EBNA1的染色体定位。该结果反驳了p32蛋白在EBNA1染色体结合中有任何作用的可能性。

Latently-infected Epstein-Barr virus(EBV) genomes are stably maintained by attaching to host chromosomes via virally-encoded EBNA1(Epstein-Barr virus Nuclear Antigen 1) protein. We examined whether cellular p32(TAP, gC1q-R) protein, a major binding partner of EBNA1, plays any role in the chromosome binding of EBNA1.Suppression of p32 expression in EBV infected cells did not affect the chromosomal localization of EBNA1.The result argues against the possibility that p32 protein has any role in the chromosome binding of EBNA1.