Imaging of oxidant stress in brain ischemia using an electromagnetic horn type ESR spectrometer

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Imaging of a free radical in the living body is useful at diagnosis of the disease of oxidant stress origin, etc. In order to perform ESR measurement of a living specimen in a status epilepticus and a brain tumor models, L-band electromagnetic horn type ESR spectrometer was developed, and compared with the conventional loop gap resonator. Although ESR measurement was completed in each model at the latter, it was difficult for a low sensitivity in the former. Combining Q-band electromagnetic horn type ESR spectrometer with a three-dimensional local ESR signal detecting ESR imaging spectrometer was devised as a remedy.