Imaging of oxidant stress in brain ischemia using an electromagnetic horn type ESR spectrometer

活体中的自由基的成像在氧化应激源等疾病的诊断中是有用的。为了在癫痫持续状态和脑肿瘤模型中进行活体样本的ESR测量，开发了L波段电磁喇叭型ESR光谱仪，并与传统的环隙谐振器进行了比较。虽然在后者的每个模型中完成了ESR测量，但在前者中由于灵敏度低而难以进行。为此，研制了Q波段电磁喇叭型ESR谱仪与三维局部ESR信号检测ESR成像谱仪相结合的方法。

Imaging of a free radical in the living body is useful at diagnosis of the disease of oxidant stress origin, etc. In order to perform ESR measurement of a living specimen in a status epilepticus and a brain tumor models, L-band electromagnetic horn type ESR spectrometer was developed, and compared with the conventional loop gap resonator. Although ESR measurement was completed in each model at the latter, it was difficult for a low sensitivity in the former. Combining Q-band electromagnetic horn type ESR spectrometer with a three-dimensional local ESR signal detecting ESR imaging spectrometer was devised as a remedy.