Geographical pathology of Kaposi's sarcoma

卡波西肉瘤的地理病理学

• 批准号: 62043059
• 负责人: ITAKURA Hideyo
• 金额: $ 1.09万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Overseas Scientific Research
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62043059/
• 关键词: Kaposi's sarcoma; Classical Kaposi's sarcoma; African endemic Kaposi's sarcoma; AIDS; Geopathology; 人類生態

Three forms of Kaposi's sarcoma (classical form, African endemic form and epidemic form of AIDS) were investigated geographically. The classification is based primarily on geographical pathology, clinical course, macroscopic appearance and microscopic characteristics of the tumors. Patients of classical KS are usually of middle or advanced age. The lesions are occasionally regressive.African endemic form is different from other form of KS by its clinical manifestations; nodular foci and various histologycal features of non-specific granulation tissue, angiosarcomatous and fibrosarcomatous lesions. KS of AIDS patients are quite characteristic with its hemorrhagic leisons and histologically angiomatous features. These findings suggest that genetical, human ecological and socioeconomical factors are significant on disease manifestations of KS.

对3种类型的卡波西肉瘤(经典型、非洲流行型和流行性艾滋病)进行了地理调查。主要根据肿瘤的地理病理、临床病程、肉眼形态和显微特征进行分类。经典型KS患者多为中老年。非洲地方性KS的临床表现、结节灶和各种组织学特征的非特异性肉芽组织、血管肉瘤和纤维肉瘤病变与其他类型的KS不同。艾滋病患者的KS具有较强的出血性病变和血管瘤的组织学特征。这些发现提示遗传、人类生态和社会经济因素对KS的疾病表现有重要影响。