Histopathology and immunopathology of Kaposi's sarcoma

卡波西肉瘤（Kaposi，1872）是一种由血管生成组织和梭形细胞组成的软组织疾病。本研究的目的是阐明以下几点的最新发现：1）组织发生：采用免疫组织化学和电子显微镜的研究表明肿瘤的起源是多能间充质细胞或血管或淋巴管的内皮细胞。2)组织学：在早期阶段，观察到皮肤水肿和炎性细胞浸润。在疾病过程中经常观察到血管瘤样模式。晚期KS由紧密交织的梭形细胞束组成。3)分类：KS在流行病学、临床和组织病理学上可分为非洲地方型、欧美经典型和AIDS流行型。4)流行病学和病理学：KS与自然环境、人类生态、社会经济条件、遗传差异的关系可能是KS发生的重要背景。我们的研究揭示了KS和伯基特淋巴瘤在东非肯尼亚的地理和种族上的巧合。

Kaposi's sarcoma (KS) (Kaposi, 1872) is a soft tissue disease composed of angiogenetic tissue and spindle-shaped cells. The purpose of this study is to elucidate the latest findings of several points as follows: 1) Histogenesis: Studies employing immunohistochemistry and electron microscopy have suggested the origin of the tumor is pulripotential mesenchymal cells or endothelial cells of blood or lymphatic vessels. 2) Histopathology: In earlier stages, cutaneous edema and inflammatory cell infiltration are observed. Hemangiosarcoma-like patterns are observed frequently in the course of the disease. KS in advanced stages is composed of compact interlacing bundles of spindle cells. 3) Classifications: KS can be classified epidemiologically, clinically and histopathologically into three forms; African endemic form, classical form in Europe and North America and epidemic form of AIDS. 4) Epidemiology and geopathology: The relationship of KS to the natural environment, human ecology, socioeconomic conditions, genetic differences may be significant as a background for the occurence of KS. Our study revealed a geographical and ethnical coincidence of KS and Burkitt's lymphoma in Kenya, East Africa.