Histopathology and immunopathology of Kaposi's sarcoma

卡波西肉瘤的组织病理学和免疫病理学

• 批准号: 59480145
• 负责人: ITAKURA Hideyo
• 金额: $ 3.58万
• 依托单位: Institute of Tropical Medicine, Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1984
• 资助国家: 日本
• 起止时间: 1984 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59480145/
• 关键词: Kaposi's sarcoma; African endemic Kaposi's sarcoma; Classical Kaposi's sarcoma; Epidemic Kaposi's sarcoma; AIDS; Histogenesis; Geopathology; Burkitt's lymphoma; Kenya; AIDS

Kaposi's sarcoma (KS) (Kaposi, 1872) is a soft tissue disease composed of angiogenetic tissue and spindle-shaped cells. The purpose of this study is to elucidate the latest findings of several points as follows: 1) Histogenesis: Studies employing immunohistochemistry and electron microscopy have suggested the origin of the tumor is pulripotential mesenchymal cells or endothelial cells of blood or lymphatic vessels. 2) Histopathology: In earlier stages, cutaneous edema and inflammatory cell infiltration are observed. Hemangiosarcoma-like patterns are observed frequently in the course of the disease. KS in advanced stages is composed of compact interlacing bundles of spindle cells. 3) Classifications: KS can be classified epidemiologically, clinically and histopathologically into three forms; African endemic form, classical form in Europe and North America and epidemic form of AIDS. 4) Epidemiology and geopathology: The relationship of KS to the natural environment, human ecology, socioeconomic conditions, genetic differences may be significant as a background for the occurence of KS. Our study revealed a geographical and ethnical coincidence of KS and Burkitt's lymphoma in Kenya, East Africa.

卡波西肉瘤（Kaposi，1872）是一种由血管生成组织和梭形细胞组成的软组织疾病。本研究的目的是阐明以下几点的最新发现：1）组织发生：采用免疫组织化学和电子显微镜的研究表明，肿瘤的起源是具有完全潜能的间充质细胞或血管或淋巴管的内皮细胞。2)组织学：在早期阶段，观察到皮肤水肿和炎性细胞浸润。在疾病过程中经常观察到血管瘤样模式。晚期KS由紧密交织的梭形细胞束组成。3)分类：KS在流行病学、临床和组织病理学上可分为非洲地方型、欧美经典型和AIDS流行型。4)流行病学和病理学：KS与自然环境、人类生态、社会经济条件、遗传差异的关系可能是KS发生的重要背景。我们的研究揭示了KS和伯基特淋巴瘤在东非肯尼亚的地理和种族上的巧合。

项目成果

Itakura,H.;Toriyama,K.: Proceedings of Int.Symp.EBV and malignant diseases. (1987)

Itakura，H.；Toriyama，K.：Int.Symp.EBV 和恶性疾病论文集。

Itakura, H. and Toriyama, K.: "Geographical pathology of Burkitt's lymphoma and Kaposi's sarcoma in western Kenya." The proceedings of 2nd Int. Symp. of EBV and malignant diseases.(1987)

Itakura, H. 和 Toriyama, K.：“肯尼亚西部伯基特淋巴瘤和卡波西肉瘤的地理病理学”。

Itakura,H.;Toriyama,K.: "Pathology of Kaposi's sarcoma" Dept.Pathol.,Inst.Trop.Med.Nagasaki University, 33 (1985)

Itakura，H.；Toriyama，K.：“卡波西肉瘤的病理学”Dept.Pathol.，Inst.Trop.Med.Nagasaki University，33（1985）

Itakura, H. and Toriyama, K.: Department of Pathology, Institute of Tropical Medicine, Nagasaki University. Pathology of Kaposi's sarcoma., 1-33 (1985)

Itakura, H. 和 Toriyama, K.：长崎大学热带医学研究所病理学系。

Itakura,H.;Toriyama,K.;Uzata,F.et al: Proceedings of Int.Symp.Kaposi's sarcoma and AIDS. (1987)

Itakura,H.；Toriyama,K.；Uzata,F.等：Int.Symp.卡波西肉瘤和艾滋病论文集。