Kaposi's sarcoma : Disease manifestations and molecular pathology

卡波西肉瘤：疾病表现和分子病理学

• 批准号: 09670193
• 负责人: ITAKURA Hideyo
• 金额: $ 1.15万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670193/
• 关键词: Kaposi's sarcoma; AIDS; Vascular proliferation; Molecular pathology; Histopathology; Soft tissue lesions; Immunopathology; Regressive change; カポシ肉腫; カボシ肉腫

Kaposi's sarcoma (KS) were studied based on hospital based histopathological observation of biopsy and surgical specimens in Africa. Relevant information and clinical data including age, sex, ethnic group, place of residence, and macroscopic appearances were collected as accurately as possible. Moreover, more than 100 cases of KS of AIDS patients and classical form in the United States and other countries were observed. The incidence and age distribution of African endemic KS were about 2.0%-5.7% of all malignant tumors in Africa and two peaks in early age and in middle to advanced age respectively. The male to female ratio was about 9 : 1. A remarkable increase in the number of cases of AIDS-KS has been observed along with the epidemic of AIDS since 1981. KS is soft tissue lesions. The predominant histological features of KS nests are fundamentally vascular proliferation and spindle-shaped cells in interspaces of the vascular tissue. The former is characterized by an angioproliferativ … More e lesion occasionally accompanied by edematous changes and a slight inflammatory cell infiltration, and the latter is characterized by dense proliferation of spindle-shaped cells, especial]y in African endemic KS. By immunopathological and molecular pathological methods, immature and mature endothelial cells and spindle-shaped cells of KS lesions show a positive reaction for mesenchymal cells. Some KS cells show regressive change in advance stage of the diseases. In our ultrastructural study of African endemic KS of the skin and lymph nodes, the capillaries of KS showed an abortive growth of the blood capillaries. Flow cytometric DNA analysis revealed that KS cells were diploid. The lesions of KS may be caused by immunological suppression or some immune factors. The disease entity of KS is still obscure. In the advanced stages of African cutaneous endemic KS, especially in older patients. Hyperplasia of angiomatous tissues and spindle-shaped cells may transform into neoplastic proliferation in the long course of the disease. KS may be a reversible hyperplasia at its inception, and in some cases, may transform into a true neoplasm at the advanced stages. However, the direct causative agents including viruses, pathogenesis and disease entity of KS are still contoversial. Less

对非洲卡波西肉瘤（KS）进行了基于医院活检和手术标本的组织病理学观察。尽可能准确地收集相关信息和临床数据，包括年龄、性别、种族、居住地和肉眼外观。并对美国等国100多例艾滋病患者KS及经典型进行了观察。非洲地方性KS的发病率和年龄分布约占非洲所有恶性肿瘤的2.0%~ 5.7%，并有两个高峰，分别出现在早期和中晚期。男女比例约为9：1。自1981年以来，沿着艾滋病的流行，艾滋病-KS病例数量显著增加。KS是软组织病变。KS巢的主要组织学特征是基本的血管增生和血管组织间隙中的梭形细胞。前者以血管增生为特征， ...更多信息 皮损中偶见水肿改变和轻度炎性细胞浸润，后者以梭形细胞密集增生为特征，尤其在非洲流行性KS中。通过免疫病理学和分子病理学方法，KS病变中未成熟和成熟的内皮细胞及梭形细胞均呈间充质细胞阳性反应。部分KS细胞在疾病晚期呈退行性改变。在我们的超微结构研究非洲地方性KS的皮肤和淋巴结，毛细血管KS显示了一个流产的毛细血管生长。流式细胞术DNA分析显示KS细胞为二倍体。KS的病变可能是由免疫抑制或某些免疫因素引起的。KS的疾病本质尚不清楚。在非洲皮肤地方性KS的晚期，特别是在老年患者中。血管瘤样组织和梭形细胞的增生在长期病程中可转化为肿瘤性增生。KS在其开始时可能是可逆的增生，并且在某些情况下，可能在晚期转化为真正的肿瘤。然而，KS的直接致病因子，包括病毒、致病机制和疾病实体，至今仍是众说纷纭。少

项目成果

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Hideyo Itakura：“发展中国家热带医学的现状和未来前景。”Trop.Med.40・4（出版中）。

Makata, AM, Itakura, H. et al.: "The pattern of pediatric solid malignant tumors in western Kenya"Am. J. Trop. Med. Hyg.. 54(4). 343-347 (1996)

Makata, AM、Itakura, H. 等人：“肯尼亚西部儿童实体恶性肿瘤的模式”Am。

Itakura, H., Toriyama, K., Kamidigo, N.O., Kusuda, M.: "Proceedings of International Symposium : Cancer epidemiology and control in Asia-Pacific region"Kaposi's sarcoma : geopathology and histopathology, Kobe Univ., Mahidol Univ., JSPS. WHO. 140-142 (1997

Itakura, H.、Toriyama, K.、Kamidigo, N.O.、Kusuda, M.：“国际研讨会论文集：亚太地区癌症流行病学和控制”卡波西肉瘤：地质病理学和组织病理学，神户大学，玛希隆大学，

Kusuda M., Itakura H. et al.: "A comparison of epidemiologic, histologic, and vivologic studies on Hodgkin's disease in western Kenya and Nagasaki, Japan"Am. J. Trop. Med. Hyg.. 59(5). 801-807 (1998)

Kusuda M.、Itakura H. 等人：“肯尼亚西部和日本长崎霍奇金病流行病学、组织学和体内学研究的比较”Am。

Itakura, H., Toriyama, K.: "Endemic diseases in Africa (I)"Gekkan Africa. 40(6), (in Japanese). 4-7 (2000)

Itakura, H., Toriyama, K.：“非洲的地方病（I）”《Gekkan Africa》。