高次脳過程の可塑性の研究

高级大脑过程的可塑性研究

• 批准号: 62121006
• 负责人: 久保田 競
• 金额: $ 11.52万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Special Project Research
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62121006/
• 关键词: GO; NO-GO課題; 学習; 連合野; GABAニューロン; 非見本合せ; 海馬

久保田はGO/NO-GO課題の学習成立におけるGABA抑制ニューロンの役割を明らかにするため, 未学習サルと学習サルの弓状野にGABA阻害剤ビククリンを局所注入し, 学習成績に対する効果を調べた. NO-GO反応を持続すること, GO反応をする事が, 出来なくなった. 又, 手の筋反応が誘発されるようになった. 未学習のサルでは, 何の変化も起こらないので, 学習の成立には抑制ニューロンの積極的活動の存在が示唆された. 甘利はシナプス効率をニューロン間の興奮・非興奮の相関で表した自己相関形連想モデルを理論的に導きだした. 平野は継時的非見本合せ課題を遂行中のラットの海馬のニューロン活動の内, 作動記憶関連活動を抽出しつつある. 酒田はサル頭頂連合野で空間記憶に基づいて手の運動を行わせている時, ニューロン活動を解析して, 空間記憶に基づいて行う手の運動に先行するニューロン活動を発見した. 二木はGO/NO-GO課題で手掛り刺激の対に対するニューロン活動が, 未学習から学習成立に至るまでの経過をサルの前頭連合野で解析した. 未学習ではGo刺激とNO-GO刺激に対する反応に差が無いが, 学習成績が90%になると, 刺激に特異的に反応するような分化したニューロン活動が見られるようになった. 学習が成立してから, 刺激と反応の関係を逆転すると, 行動的意味の変換によって, ニューロン活動が変化した. 高松はニワトリで刷り込み学習時に前頭蓋部の一部(MHV)でGABA受容体の結合能の変化をムシモルを使って調べた. 刷り込み刺激の呈示直後, 特異的に結合能の増加を認めた. 抑制ニューロン活動が学習に関与することが示唆された. 岩田は半側空間無視を示す脳損傷患者で瞬間露出光刺激テストや描画テストを行って, 視覚障害と無視の関係を調べたが, 半側無視は体軸の双方で見つかり, 必ずしも体側に限局していなかった. 障害は過去の記憶の中にも体側無視として現れた.

Kubota GO/NO-GO Engineering Institute set up a research program, which is called GABA suppression, and has not learned how to use the arched field GABA to prevent the damage caused by the arched field, and to learn the effect of the injection. NO-GO said nothing about it, while GO did not say anything about it. Come out and let it go. At the same time, the hand tendons are so tight that they don't know what to do. If you haven't learned how to do something about it, you can start to do it. If you set up a program, you can inhibit the existence of active activities that show instigation. Ganli is interested in the number of people who are interested in the theory of theory. During the operation of the non-cost joint project during the Hirano period, during the operation of the project, the activity record was drawn out of the activity program. In the field, please contact the field records. When the mobile phone is running, the activity will be parsed, and the space record will be read in advance. The second wooden GO/NO-GO project is designed to stimulate the activities of the students, who have not learned how to do the work, and have not studied the establishment of the training program. If you haven't learned how to stimulate Go, you have not learned how to stimulate NO-GO, so that you can learn more than 90% of what you are going to do, and then you can stimulate your response to differentiation. The Institute of Science and Technology has set up a training program to stimulate anti-terrorism activities, which means that activities will be conducted in response, and activities will be activated. Takamatsu uses the first part of the (MHV) GABA receptive body to make sure that the device can be used to improve the performance of the device. After the brush stimulus is presented, the combination of the special device can increase the frequency of the stimulus. Instigate instigation and instigation of instigation in the suppression of medical activities. The half-space of the Iwata camera shows that the patient is instantly exposed to light stimulation, the camera is drawing the camera, the damage is not watching the camera, and both sides of the camera are in contact with each other. it is necessary to do so. In the past, the system did not pay attention to the health problems in the past.