Porous Capsules' Interactions with Corks and Simultaneously Smaller Entering Cations: Sphere Surface Supramolecular Chemistry and Modeling Biological Cation Transport - Novel Synthetic and NMR Studies

多孔胶囊与软木塞的相互作用以及同时较小的进入阳离子：球体表面超分子化学和生物阳离子传输建模 - 新颖的合成和核磁共振研究

• 批准号: 51134662
• 负责人: Dr. Erhard T. K. Haupt (†)
• 金额: --
• 依托单位: Institut für Anorganische und Angewandte Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/51134662?language=en
• 关键词: Porous; Capsules; Interactions; Corks; Simultaneously

Our work focuses on unique molybdenum oxide-based porous capsules which allow to study nanoscaled cation separation and dynamics, and model cells with respect to (i) trans-membrane cation transport across the pores and (ii) design and fine-tuning of the cavity, so as to provide hydrophilic or hydrophobic conditions, by attachment of appropriate ligands to the oxidomolybdenum framework. We intend to supplement the work accomplished in the bygone two-and-a-half years by extending and refining the interior equipment of the capsules, and by rarefying, through multinuclear NMR, the methodological aspects of the investigation and the analysis of the dynamics of intracellular incidents, including guest exchange within the cavity and intra/extra-"cellular" exchange of organic building blocks (ligands). Furthermore, it is intended to study new phenomena, e.g. dynamical exchange equilibria within the capsules.

我们的工作重点是独特的氧化钼为基础的多孔胶囊，允许研究纳米级的阳离子分离和动力学，模型细胞（i）跨膜阳离子运输的孔和（ii）设计和微调的空腔，以便提供亲水或疏水的条件，通过适当的配体连接到氧化钼框架。我们打算通过扩展和改进胶囊的内部设备来补充过去两年半中完成的工作，并通过多核NMR，调查和分析细胞内事件的动力学的方法学方面，包括空腔内的客体交换和有机构建块（配体）的内/外“细胞”交换。此外，还打算研究新的现象，例如胶囊内的动态交换平衡。

项目成果

Cellular cation transport studied by 6, 7Li and 23Na NMR in a porous Mo132 Keplerate type nano‐capsule as model system

• DOI: 10.1002/mrc.2343
• 发表时间: 2008
• 期刊: Magnetic Resonance in Chemistry
• 影响因子: 2
• 作者: D. Rehder;E. Haupt;A. Müller

Cation behavior at an artificial cell interface: binding distinguished by ion hydration energetics and size.

• DOI: 10.1039/b718260k
• 发表时间: 2008-02
• 期刊: Chemical communications
• 影响因子: 4.9
• 作者: Alice Merca;H. Bögge;M. Schmidtmann;Yunshan Zhou;Erhard T. K. Haupt;M. Khaled Sarker;C. Hill;A. Müller

Confinement and step-wise reopening of channels in an artificial cell/inorganic capsule: a 7Li NMR study.

• DOI: 10.1002/chem.200801122
• 发表时间: 2008-10
• 期刊: Chemistry
• 作者: E. Haupt;Claudia Wontorra;D. Rehder;Alice Merca;A. Müller