Porous Capsules' Interactions with Corks and Simultaneously Smaller Entering Cations: Sphere Surface Supramolecular Chemistry and Modeling Biological Cation Transport - Novel Synthetic and NMR Studies

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Our work focuses on unique molybdenum oxide-based porous capsules which allow to study nanoscaled cation separation and dynamics, and model cells with respect to (i) trans-membrane cation transport across the pores and (ii) design and fine-tuning of the cavity, so as to provide hydrophilic or hydrophobic conditions, by attachment of appropriate ligands to the oxidomolybdenum framework. We intend to supplement the work accomplished in the bygone two-and-a-half years by extending and refining the interior equipment of the capsules, and by rarefying, through multinuclear NMR, the methodological aspects of the investigation and the analysis of the dynamics of intracellular incidents, including guest exchange within the cavity and intra/extra-"cellular" exchange of organic building blocks (ligands). Furthermore, it is intended to study new phenomena, e.g. dynamical exchange equilibria within the capsules.