Epidemiology of neurophysiological parameters of the brain using transcranial magnetic stimulation

经颅磁刺激(TMS)使非侵入性和活体研究人脑的兴奋性成为可能。尽管在神经学临床诊断学和神经科学研究中使用了大量的研究，但到目前为止还没有关于具有人口代表性的大型队列的系统的流行病学研究。该应用的目的是将TMS引入德国最大的流行病学研究之一(波美拉尼亚船上的健康研究)的新的研究人群。首次使用简单的TMS参数来确定大脑(初级)的兴奋性与其促进和抑制(次级)之间的关系。2000人参加。这将是第一次有可能在更大范围内创建与各种个体变量相关的神经生理学正常值，例如年龄、性别或身高。这样的队列还能够验证当前在特定神经精神疾病(例如头痛和抑郁症)和系统性疾病(例如糖尿病)方面对高度选择的人群的研究。因此，结果将有助于在诊断常规的背景下以及在神经科学的进一步扩大的领域中更好地理解个体价值。此外，它还推动了神经生理学和治疗方法的发展。

Transcranial magnetic stimulation (TMS) enables a non-invasive and in vivo investigation of the excitability of the human brain. Although used in neurological clinical diagnostics and in neuroscientific research in a large number of studies, no systematic, epidemiological studies on a large, population-representative cohort are available up to date.The aim of this application is to introduce TMS into a new study population of one of the largest epidemiological studies in Germany (Study of Health In Pomerania SHIP). For the first time, the relationship between the excitability of the brain (primary) and its facilitation and inhibition (secondary) will be determined using simple TMS-parameters on a total population of approx. 2000 participants. For the first time it will be possible to create neurophysiological norm values in relation to various individual variables such as age, sex or height on a larger scale. Such a cohort also enables to validate current studies of highly selected populations in specific neurological-psychiatric (e.g. headaches and depression) and systemic diseases (e.g. diabetes mellitus).The results therefore will help to better understand the individual values in the context of diagnostic routine as well as in the further expanding field of neuroscience. Furthermore, it drives the development of neurophysiological and therapeutic approaches.