Functional evolution of pigment synthesis pathways in teleost fish through gen(om)e duplication

硬骨鱼色素合成途径通过基因（om）e复制的功能进化

• 批准号: 51155556
• 负责人: Professor Dr. Manfred Schartl, Ph.D.
• 金额: --
• 依托单位: Lehrstuhl für Entwicklungsbiochemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/51155556?language=en
• 关键词: Functional; evolution; pigment; synthesis; pathways

Whole genome duplications have been proposed to correspond to major evolutionary events possibly associated with important biological transitions, major leaps in evolution and adaptive radiations of species. Using a multidisciplinary comparative approach combining bioinformatics with molecular, evolutionary and developmental biology, this project aims to better understand the functional consequences of genome duplications on biological processes. More specifically, this analysis will focus on the evolutionary impact of an ancestral fish-specific genome duplication (FSGD) on pigmentation, and its possible causal relationship with the huge diversity of coloration and color patterning observed in teleosts. Using the five fish genome drafts available so far, as well as sequence data and biological material from other representative teleost species, a catalogue of duplicated pigmentation genes will be systematically established. In order to assess the evolutionary mechanisms behind the persistence of such duplicates over about 300 million years of evolution, their expression pattern and function will be analyzed and compared to the single copy genes in tetrapods. Importantly, duplicated genes will be analyzed in different fish lineages, since differential evolution of duplicates after whole genome duplications might significantly contribute to speciation and other forms of biodiversity.

全基因组复制被认为与重大的进化事件相对应，这些事件可能与重要的生物学转变、进化的重大飞跃和物种的适应性辐射有关。利用生物信息学与分子、进化和发育生物学相结合的多学科比较方法，该项目旨在更好地了解基因组复制对生物过程的功能性后果。更具体地说，这项分析将集中在一个祖先鱼特异性基因组重复（FSGD）对色素沉着的进化影响，以及其可能的因果关系与硬骨鱼中观察到的巨大多样性的着色和颜色图案。利用迄今为止可获得的五种鱼类基因组草图，以及其他代表性硬骨鱼物种的序列数据和生物材料，将系统地建立重复色素基因的目录。为了评估这种重复在大约3亿年的进化中持续存在背后的进化机制，将分析它们的表达模式和功能，并与四足动物中的单拷贝基因进行比较。重要的是，复制的基因将在不同的鱼类谱系中进行分析，因为全基因组复制后复制品的差异进化可能会对物种形成和其他形式的生物多样性做出重大贡献。