Deactivation potential of cold atmospheric plasma for viruses and bacteria in exhalation-generated aerosol droplets

冷大气等离子体对呼气产生的气溶胶液滴中的病毒和细菌的灭活潜力

• 批准号: 511873613
• 负责人: Professorin Dr. Nina Merkert
• 金额: --
• 依托单位: Institut für Technische Mechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/511873613?language=en
• 关键词: Deactivation; potential; cold; atmospheric; plasma

The use of cold atmospheric plasma has attracted a lot of attention over the past few years and has already found many biomedical applications. The Covid 19 pandemic has increased the demand for the inactivation of viruses in aerosol particles. Atomistic simulations can provide fundamental insights into this process. However, the investigation of ions, and vibrationally excited molecules needs further investigations. Most bio-organisms, including the Corona virus, have a liquid film surrounding them. Therefore, it is necessary to understand which interactions between the plasma and the liquid reactions carried out, before the plasma species reach the surface of the bio-organisms. To gain a better understanding of this behavior, we will combine experimental aerosol measurements with molecular dynamics (MD) simulations to examine the chemical reactions between gaseous reactive oxygen and nitrogen species and water molecules. We will answer the research question if the plasma generated charged species recombine before they reach the virus. We will study the effect of plasma reactive species on the structure of the spike (S) glycoprotein, that plays a key role in the pathogenicity, transmission, and evolution of coronaviruses. The aim of the project is to find ideal process conditions for plasma disinfection taking into account liquid layers.

在过去的几年里，冷大气等离子体的使用引起了人们的极大关注，并已经在生物医学上得到了许多应用。Covid 19大流行增加了对气溶胶颗粒中病毒灭活的需求。原子模拟可以提供对这一过程的基本见解。然而，对离子和振动激发分子的研究还需要进一步的研究。大多数生物，包括冠状病毒，都有一层液膜围绕着它们。因此，有必要了解在等离子体物种到达生物有机体表面之前，等离子体和液体之间发生了哪些相互作用。为了更好地了解这一行为，我们将结合实验气溶胶测量和分子动力学(MD)模拟来研究气态活性氧和氮物种与水分子之间的化学反应。如果等离子体产生的带电物种在到达病毒之前重新组合，我们将回答这个研究问题。我们将研究血浆活性物质对SPEKE(S)糖蛋白结构的影响，该糖蛋白在冠状病毒的致病、传播和进化中发挥关键作用。该项目的目的是在考虑液层的情况下，找到理想的等离子体消毒工艺条件。