Fundamentals of plasma disinfection for the inactivation of viruses in aerosol particles: Influence of liquid films

等离子消毒灭活气溶胶颗粒中病毒的基本原理：液膜的影响

• 批准号: 468784496
• 负责人: Professorin Dr. Nina Merkert
• 金额: --
• 依托单位: Institut für Technische Mechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/468784496?language=en
• 关键词: Fundamentals; plasma; disinfection; inactivation; viruses

Cold atmospheric plasmas such as Dielectric Barrier Discharge (DBD) plasmas are used to inactivate microorganisms and to eliminate toxic or undesirable pollutants in air or exhaust streams and are even employed to selectively target the destruction of cancer cells. The Covid-19 pandemic raised the demand for inactivation of viruses in aerosol particles. One idea is to filter the particles and then use cold plasma to eliminate the viruses. The other approach is to inactivate the viruses directly in the aerosol state. However, in the case of liquid aerosol particles, the viruses are surrounded by moisture layers and the interaction between the plasma species and the liquid layer is still poorly understood.Atomistic simulations can provide fundamental insights into plasma disinfection processes that are difficult to access, especially in the aerosol state, through experiments. In this project, molecular dynamics simulations will be performed to investigate the interaction mechanisms of reactive plasma species with liquid films surrounding viruses. The plasma membrane of the virus will be modeled as a lipid bilayer. The concentration of the active species at the plasma source and their decay over time will be directly determined from experiments using UV-vis spectroscopy of the DBD plasma and a radical sensitive tracer reaction.

冷大气等离子体，如介质阻挡放电(DBD)等离子体，被用来灭活微生物，消除空气或废气中的有毒或有害污染物，甚至被用来选择性地破坏癌细胞。新冠肺炎的大流行提高了对气溶胶颗粒中病毒灭活的需求。一种想法是过滤颗粒，然后使用冷等离子体来消除病毒。另一种方法是在气溶胶状态下直接灭活病毒。然而，在液体气溶胶粒子的情况下，病毒被湿润层包围，等离子体物种与液体层之间的相互作用仍未得到很好的了解。原子模拟可以通过实验提供对难以访问的等离子体消毒过程的基本见解，特别是在气溶胶状态下。在这个项目中，分子动力学模拟将被用来研究反应等离子体物种与病毒周围的液膜的相互作用机制。病毒的质膜将被模拟为脂质双层。使用DBD等离子体的UV-Vis光谱和自由基敏感示踪反应的实验将直接确定等离子体源中活性物种的浓度及其随时间的衰减。