Total Synthesis of Novel Metabolites form Microorganisms

微生物新型代谢物的全合成

• 批准号: DP0449522
• 负责人: Prof Mark Rizzacasa
• 金额: $ 16.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-14 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0449522
• 关键词: Total; Synthesis; Novel; Metabolites; form

The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal metabolite zaragozic acid C.

该提案的主要目的是实现从微生物中分离的一些具有生物活性的新型天然产物的化学合成。这将涉及开发新方法以及改进迄今为止开发的认证方法。目标将包括粘细菌代谢物crocacin A、B和D以及apicularen A，链霉菌代谢物reveromycin A和spirofungin A以及真菌代谢物zaragozic acid C。