Total Synthesis of Novel Metabolites form Microorganisms

本提案的主要目的是实现从微生物中分离出的一些具有生物活性的新型天然产物的化学合成。这将涉及发展新方法以及改进迄今为止发展的现有办法。目标将包括黏菌的代谢物鳄鱼霉素A、B和D和尖孢菌A，链霉菌的代谢物reveromycin A和spirofungin A以及真菌的代谢物zaragozic酸C。

The main aim of this proposal is to achieve the chemical synthesis of a number of biologically active novel natural products isolated from microorganisms. This will involve the development of new methods as well as improvement on exisiting approaches developed so far. The targets will include the myxobacteria metabolites crocacins A, B and D and apicularen A, the streptomyces metabolites reveromycin A and spirofungin A and the fungal metabolite zaragozic acid C.