Lessons From Nature: Late Stage Oxidation in Total Synthesis

大自然的教训：全合成的后期氧化

• 批准号: DP220100905
• 负责人: Prof Mark Rizzacasa
• 金额: $ 39.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-24 至 2025-01-24
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220100905
• 关键词: Lessons; Nature; Late; Stage; Oxidation

This project aims to achieve the chemical synthesis of a number of biologically active novel natural products. The key aspect is the application of chemistry inspired by Nature to deliver molecular complexity in a rapid fashion which would allow for the production of molecules otherwise unavailable in sufficient quantities from the natural sources. This research will utilize late stage oxidation of intermediates to provide ready access to complex molecules. The main goal is the development of new chemical and biological catalysts for further application in organic synthesis with a view to the production of new medicinal agents and important materials.

本项目旨在实现一些具有生物活性的新型天然产物的化学合成。关键方面是应用受大自然启发的化学，以快速方式提供分子复杂性，这将允许生产分子，否则无法从天然来源获得足够的数量。这项研究将利用中间体的后期氧化，以提供现成的复杂分子。主要目标是开发新的化学和生物催化剂，进一步应用于有机合成，以生产新的药物和重要材料。